Insulin Signaling in Bone Marrow Adipocytes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Insulin Signaling in Bone Marrow Adipocytes. / Tencerova, Michaela; Okla, Meshail; Kassem, Moustapha.
I: Current Osteoporosis Reports, Bind 17, Nr. 6, 2019, s. 446-454.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Insulin Signaling in Bone Marrow Adipocytes
AU - Tencerova, Michaela
AU - Okla, Meshail
AU - Kassem, Moustapha
PY - 2019
Y1 - 2019
N2 - Purpose of Review: The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases. Recent Findings: Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. Summary: This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.
AB - Purpose of Review: The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases. Recent Findings: Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. Summary: This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.
KW - Bone marrow adipose tissue
KW - Bone marrow mesenchymal stem cells
KW - Insulin signaling
KW - Marrow adiposity
U2 - 10.1007/s11914-019-00552-8
DO - 10.1007/s11914-019-00552-8
M3 - Review
C2 - 31749085
AN - SCOPUS:85075362215
VL - 17
SP - 446
EP - 454
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
SN - 1544-1873
IS - 6
ER -
ID: 234638312