Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.
Originalsprog | Engelsk |
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Artikelnummer | 83 |
Tidsskrift | Current Diabetes Reports |
Vol/bind | 15 |
Udgave nummer | 10 |
ISSN | 1534-4827 |
DOI | |
Status | Udgivet - 22 okt. 2015 |
Eksternt udgivet | Ja |
ID: 226395607