Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens
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Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens. / Askjaer, N; Maxwell, C; Chambo, W; Staalsoe, T; Nielsen, Morten Agertoug; Hviid, L; Curtis, C; Theander, T G.
I: Clinical and Vaccine Immunology, Bind 8, Nr. 6, 2001, s. 1289-91.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens
AU - Askjaer, N
AU - Maxwell, C
AU - Chambo, W
AU - Staalsoe, T
AU - Nielsen, Morten Agertoug
AU - Hviid, L
AU - Curtis, C
AU - Theander, T G
N1 - Keywords: Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Beds; Child; Child, Preschool; Humans; Immune System; Insecticides; Malaria, Falciparum
PY - 2001
Y1 - 2001
N2 - The use of insecticide-treated bed nets (ITN) has been documented to reduce malaria morbidity and mortality in areas with endemic malaria, but concerns have been raised that ITN usage could affect the acquisition of malaria immunity. Several lines of evidence have indicated that antibodies against variant surface antigens (VSA) are important in the development of naturally acquired immunity to Plasmodium falciparum malaria and may thus be good indicators of immune status. We have compared the levels of VSA antibodies in plasma from children who have used ITN for 4 years to levels in plasma from children from a nearby village not using ITN. A total of 97 plasma samples were analyzed using 13 different P. falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN.
AB - The use of insecticide-treated bed nets (ITN) has been documented to reduce malaria morbidity and mortality in areas with endemic malaria, but concerns have been raised that ITN usage could affect the acquisition of malaria immunity. Several lines of evidence have indicated that antibodies against variant surface antigens (VSA) are important in the development of naturally acquired immunity to Plasmodium falciparum malaria and may thus be good indicators of immune status. We have compared the levels of VSA antibodies in plasma from children who have used ITN for 4 years to levels in plasma from children from a nearby village not using ITN. A total of 97 plasma samples were analyzed using 13 different P. falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN.
U2 - 10.1128/CDLI.8.6.1289-1291.2001
DO - 10.1128/CDLI.8.6.1289-1291.2001
M3 - Journal article
C2 - 11687480
VL - 8
SP - 1289
EP - 1291
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
SN - 1556-6811
IS - 6
ER -
ID: 6747173