Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males
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Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males. / Juel Mortensen, Li; Kooij, Ireen; Lorenzen, Mette; Rye Jørgensen, Niklas; Røder, Andreas; Jørgensen, Anne; Andersson, Anna Maria; Juul, Anders; Blomberg Jensen, Martin.
I: Cell Calcium, Bind 122, 102908, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males
AU - Juel Mortensen, Li
AU - Kooij, Ireen
AU - Lorenzen, Mette
AU - Rye Jørgensen, Niklas
AU - Røder, Andreas
AU - Jørgensen, Anne
AU - Andersson, Anna Maria
AU - Juul, Anders
AU - Blomberg Jensen, Martin
N1 - Publisher Copyright: © 2024
PY - 2024
Y1 - 2024
N2 - Animal and human studies have suggested that sex steroids have calciotropic actions, and it has been proposed that follicle-stimulating hormone (FSH) may exert direct effects on bone. Here, we demonstrate the expression of the receptor for Luteinizing hormone (LH) and human choriogonadotropin (hCG), LHCGR, in human kidney tissue, suggesting a potential influence on calcium homeostasis. To investigate the role of LHCGR agonist on calcium homeostasis in vivo, we conducted studies in male mice and human subjects. Male mice were treated with luteinizing hormone (LH), and human extrapolation was achieved by injecting 5000 IU hCG once to healthy men or men with hypergonadotropic or hypogonadotropic hypogonadism. In mice, LH treatment significantly increased urinary calcium excretion and induced a secondary increase in serum parathyroid hormone (PTH). Similarly, hCG treatment in healthy men led to a significant increase in urinary calcium excretion, serum PTH levels, and 1,25 (OH)2D3, while calcitonin, and albumin levels were reduced, possibly to avoid development of persistent hypocalcemia. Still, the rapid initial decline in ionized calcium coincided with a significant prolongation of the cardiac QTc-interval that normalized over time. The observed effects may be attributed to LH/hCG-receptor (LHCGR) activation, considering the presence of LHCGR expression in human kidney tissue, and the increase in sex steroids occurred several hours after the changes in calcium homeostasis. Our translational study shed light on the intricate relationship between gonadotropins, sex hormones and calcium, suggesting that LHCGR may be influencing calcium homeostasis directly or indirectly.
AB - Animal and human studies have suggested that sex steroids have calciotropic actions, and it has been proposed that follicle-stimulating hormone (FSH) may exert direct effects on bone. Here, we demonstrate the expression of the receptor for Luteinizing hormone (LH) and human choriogonadotropin (hCG), LHCGR, in human kidney tissue, suggesting a potential influence on calcium homeostasis. To investigate the role of LHCGR agonist on calcium homeostasis in vivo, we conducted studies in male mice and human subjects. Male mice were treated with luteinizing hormone (LH), and human extrapolation was achieved by injecting 5000 IU hCG once to healthy men or men with hypergonadotropic or hypogonadotropic hypogonadism. In mice, LH treatment significantly increased urinary calcium excretion and induced a secondary increase in serum parathyroid hormone (PTH). Similarly, hCG treatment in healthy men led to a significant increase in urinary calcium excretion, serum PTH levels, and 1,25 (OH)2D3, while calcitonin, and albumin levels were reduced, possibly to avoid development of persistent hypocalcemia. Still, the rapid initial decline in ionized calcium coincided with a significant prolongation of the cardiac QTc-interval that normalized over time. The observed effects may be attributed to LH/hCG-receptor (LHCGR) activation, considering the presence of LHCGR expression in human kidney tissue, and the increase in sex steroids occurred several hours after the changes in calcium homeostasis. Our translational study shed light on the intricate relationship between gonadotropins, sex hormones and calcium, suggesting that LHCGR may be influencing calcium homeostasis directly or indirectly.
KW - Calcium
KW - Calcium homeostasis
KW - Endocrine cross-talk
KW - Excretion
KW - Human chorionic gonadotropin
KW - LHCGR expression
KW - Luteinizing hormone
KW - Males
KW - Translational research
U2 - 10.1016/j.ceca.2024.102908
DO - 10.1016/j.ceca.2024.102908
M3 - Journal article
C2 - 38852333
AN - SCOPUS:85195369032
VL - 122
JO - Cell Calcium
JF - Cell Calcium
SN - 0143-4160
M1 - 102908
ER -
ID: 395072313