Informativeness of genetic markers for forensic inference--An information theoretic approach
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Informativeness of genetic markers for forensic inference--An information theoretic approach. / Lauritzen, Steffen L.; Mazumder, Anjali.
I: Forensic Science International: Genetics Supplement Series, Bind 1, Nr. 1, 01.08.2008, s. 652-653.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Informativeness of genetic markers for forensic inference--An information theoretic approach
AU - Lauritzen, Steffen L.
AU - Mazumder, Anjali
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Forensic inference from genetic markers uses highly polymorphic multi-locus genotypes. Measures of informativeness can aid in selecting efficient genetic markers. Existing measures do not account for multiple sources of genetic variation (i.e. mutation, silent alleles, etc.) and they are not directly applicable to complex identification problems. Using information theoretic principles within a probabilistic expert system (PES) we define a general measure of informativeness, Iq, of a marker for answering a forensic query. Iq gives a slightly different ranking of most genetic markers as its comparable measures. Accounting for sources of variation such as mutation, silent and null alleles reduces Iq and may further affect ranking. This criterion has a solid theoretical basis and can account for multiple sources of genetic variation and other anomalies. It can be directly applied to a variety of planning issues concerning the type, quantity and specific choice of markers for use in paternity testing and more general forensic problems.
AB - Forensic inference from genetic markers uses highly polymorphic multi-locus genotypes. Measures of informativeness can aid in selecting efficient genetic markers. Existing measures do not account for multiple sources of genetic variation (i.e. mutation, silent alleles, etc.) and they are not directly applicable to complex identification problems. Using information theoretic principles within a probabilistic expert system (PES) we define a general measure of informativeness, Iq, of a marker for answering a forensic query. Iq gives a slightly different ranking of most genetic markers as its comparable measures. Accounting for sources of variation such as mutation, silent and null alleles reduces Iq and may further affect ranking. This criterion has a solid theoretical basis and can account for multiple sources of genetic variation and other anomalies. It can be directly applied to a variety of planning issues concerning the type, quantity and specific choice of markers for use in paternity testing and more general forensic problems.
KW - Bayesian networks
KW - Entropy
KW - Mutual information
KW - Paternity testing
KW - Planning
KW - Probabilistic expert systems
UR - http://www.scopus.com/inward/record.url?scp=50349091227&partnerID=8YFLogxK
U2 - 10.1016/j.fsigss.2007.10.144
DO - 10.1016/j.fsigss.2007.10.144
M3 - Journal article
AN - SCOPUS:50349091227
VL - 1
SP - 652
EP - 653
JO - Forensic Science International: Genetics. Supplement Series
JF - Forensic Science International: Genetics. Supplement Series
SN - 1875-1768
IS - 1
ER -
ID: 218403137