Influence of exercise intensity on skeletal muscle blood flow, O2 extraction and O2 uptake on-kinetics
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Influence of exercise intensity on skeletal muscle blood flow, O2 extraction and O2 uptake on-kinetics. / Jones, Andrew M; Krustrup, Peter; Wilkerson, Daryl P; Berger, Nicolas J; Calbet, José A; Bangsbo, Jens.
I: Journal of Physiology, Bind 590, Nr. 17, 2012, s. 4363-4376.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Influence of exercise intensity on skeletal muscle blood flow, O2 extraction and O2 uptake on-kinetics
AU - Jones, Andrew M
AU - Krustrup, Peter
AU - Wilkerson, Daryl P
AU - Berger, Nicolas J
AU - Calbet, José A
AU - Bangsbo, Jens
N1 - CURIS 2012 5200 118
PY - 2012
Y1 - 2012
N2 - Key points Following the start of low-intensity exercise in healthy humans, it has been established that the kinetics of muscle O(2) delivery is faster than, and does not limit, the kinetics of muscle O(2) uptake. Direct data are lacking, however, on the question of whether O(2) delivery might limit O(2) uptake kinetics during high-intensity exercise. In this study, we made frequent measurements of muscle blood flow, arterial-to-venous O(2) difference (a- difference) and O(2) uptake following the onset of multiple transitions of both low-intensity and high-intensity knee-extension exercise in the same subjects. We show that although blood flow kinetics is slower for high-intensity compared with low-intensity exercise, this does not result in slower O(2) uptake kinetics. These results indicate that muscle O(2) delivery does not limit O(2) uptake during knee-extension exercise in healthy humans.
AB - Key points Following the start of low-intensity exercise in healthy humans, it has been established that the kinetics of muscle O(2) delivery is faster than, and does not limit, the kinetics of muscle O(2) uptake. Direct data are lacking, however, on the question of whether O(2) delivery might limit O(2) uptake kinetics during high-intensity exercise. In this study, we made frequent measurements of muscle blood flow, arterial-to-venous O(2) difference (a- difference) and O(2) uptake following the onset of multiple transitions of both low-intensity and high-intensity knee-extension exercise in the same subjects. We show that although blood flow kinetics is slower for high-intensity compared with low-intensity exercise, this does not result in slower O(2) uptake kinetics. These results indicate that muscle O(2) delivery does not limit O(2) uptake during knee-extension exercise in healthy humans.
U2 - 10.1113/jphysiol.2012.233064
DO - 10.1113/jphysiol.2012.233064
M3 - Journal article
C2 - 22711961
VL - 590
SP - 4363
EP - 4376
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 17
ER -
ID: 40924697