Increased risk for depression after breast cancer: a nationwide population-based cohort study of associated factors in Denmark, 1998-2011
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Increased risk for depression after breast cancer : a nationwide population-based cohort study of associated factors in Denmark, 1998-2011. / Suppli, Nis P; Johansen, Christoffer; Christensen, Jane; Kessing, Lars V; Kroman, Niels; Dalton, Susanne O.
I: Journal of Clinical Oncology, Bind 32, Nr. 34, 01.12.2014, s. 3831-3839.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased risk for depression after breast cancer
T2 - a nationwide population-based cohort study of associated factors in Denmark, 1998-2011
AU - Suppli, Nis P
AU - Johansen, Christoffer
AU - Christensen, Jane
AU - Kessing, Lars V
AU - Kroman, Niels
AU - Dalton, Susanne O
N1 - © 2014 by American Society of Clinical Oncology.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - PURPOSE: To investigate the risk for first depression, assessed as incident hospital contacts for depression and incident use of antidepressants, among women with breast cancer.PATIENTS AND METHODS: Danish national registries were used to identify 1,997,669 women with no diagnosis of cancer or a major psychiatric disorder. This cohort was followed from 1998 to 2011 for a diagnosis of breast cancer and for the two outcomes, hospital contact for depression and redeemed prescriptions for antidepressants. Rate ratios for incident hospital contacts for depression and incident use of antidepressants were estimated with Poisson regression models. Multivariable Cox regression was used to evaluate factors associated with the two outcomes among patients with breast cancer.RESULTS: We identified 44,494 women with breast cancer. In the first year after diagnosis, the rate ratio for a hospital contact for depression was 1.70 (95% CI 1.41 to 2.05) and that for use of antidepressants was 3.09 (95% CI 2.95 to 3.22); these rate ratios were significantly increased after 3 and 8 years, respectively. Comorbidity, node-positive disease, older age, basic and vocational educational levels, and living alone were associated with use of antidepressants.CONCLUSION: Women with breast cancer are at long-term increased risk for first depression, including both severe episodes leading to hospital contact and use of antidepressants. Clinicians should be aware that the risk is highest in women with comorbid conditions, node-positive disease, and age of 70 years or more. We found no clear association between type of surgery or adjuvant treatment and risk for depression.
AB - PURPOSE: To investigate the risk for first depression, assessed as incident hospital contacts for depression and incident use of antidepressants, among women with breast cancer.PATIENTS AND METHODS: Danish national registries were used to identify 1,997,669 women with no diagnosis of cancer or a major psychiatric disorder. This cohort was followed from 1998 to 2011 for a diagnosis of breast cancer and for the two outcomes, hospital contact for depression and redeemed prescriptions for antidepressants. Rate ratios for incident hospital contacts for depression and incident use of antidepressants were estimated with Poisson regression models. Multivariable Cox regression was used to evaluate factors associated with the two outcomes among patients with breast cancer.RESULTS: We identified 44,494 women with breast cancer. In the first year after diagnosis, the rate ratio for a hospital contact for depression was 1.70 (95% CI 1.41 to 2.05) and that for use of antidepressants was 3.09 (95% CI 2.95 to 3.22); these rate ratios were significantly increased after 3 and 8 years, respectively. Comorbidity, node-positive disease, older age, basic and vocational educational levels, and living alone were associated with use of antidepressants.CONCLUSION: Women with breast cancer are at long-term increased risk for first depression, including both severe episodes leading to hospital contact and use of antidepressants. Clinicians should be aware that the risk is highest in women with comorbid conditions, node-positive disease, and age of 70 years or more. We found no clear association between type of surgery or adjuvant treatment and risk for depression.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antidepressive Agents
KW - Breast Neoplasms
KW - Denmark
KW - Depression
KW - Drug Prescriptions
KW - Female
KW - Hospitalization
KW - Humans
KW - Incidence
KW - Middle Aged
KW - Multivariate Analysis
KW - Outpatient Clinics, Hospital
KW - Proportional Hazards Models
KW - Registries
KW - Risk Assessment
KW - Risk Factors
KW - Time Factors
U2 - 10.1200/JCO.2013.54.0419
DO - 10.1200/JCO.2013.54.0419
M3 - Journal article
C2 - 25349294
VL - 32
SP - 3831
EP - 3839
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 34
ER -
ID: 137511570