Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Anticancer Research |
Vol/bind | 25 |
Udgave nummer | 6B |
Sider (fra-til) | 3781-9 |
Antal sider | 9 |
ISSN | 0250-7005 |
Status | Udgivet - 2011 |
Eksternt udgivet | Ja |
ID: 35457528