Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria
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Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria. / Jakobsen, P H; McKay, V; Morris-Jones, S D; McGuire, W; van Hensbroek, M B; Meisner, S; Bendtzen, K; Schousboe, I; Bygbjerg, I C; Greenwood, B M.
I: Infection and Immunity, Bind 62, Nr. 10, 1994, s. 4374-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria
AU - Jakobsen, P H
AU - McKay, V
AU - Morris-Jones, S D
AU - McGuire, W
AU - van Hensbroek, M B
AU - Meisner, S
AU - Bendtzen, K
AU - Schousboe, I
AU - Bygbjerg, I C
AU - Greenwood, B M
N1 - Keywords: Antibodies, Protozoan; Child, Preschool; Female; Gambia; Glycoproteins; Humans; Immunoglobulin M; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Malaria, Cerebral; Male; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; beta 2-Glycoprotein I
PY - 1994
Y1 - 1994
N2 - To investigate the pathogenic versus the protective role of cytokines and toxin-binding factors in Plasmodium falciparum infections, we measured the concentrations of tumor necrosis factor alpha, interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor antagonist, and IL-6, as well as soluble receptors of tumor necrosis factor and IL-6 (sIL-6R) in serum of Gambian children with cerebral malaria, mild or asymptomatic malaria, or other illnesses unrelated to malaria. Because cytokine secretion may be triggered by toxic structures containing phosphatidylinositol (PI), we also measured concentrations of anti-PI antibodies and the PI-binding serum protein beta-2-glycoprotein I. We found increased concentrations of IL-6, sIL-6R, IL-1ra, and some immunoglobulin M antibodies against PI in children with cerebral malaria, but those who died had decreased concentrations of beta-2-glycoprotein I. We conclude that increased concentrations of cytokines and soluble cytokine receptors represent a normal host response to P. falciparum infections but that excessive secretion of cytokines like IL-6 may predispose to cerebral malaria and a fatal outcome while beta-2-glycoprotein I may protect against a fatal outcome of cerebral malaria.
AB - To investigate the pathogenic versus the protective role of cytokines and toxin-binding factors in Plasmodium falciparum infections, we measured the concentrations of tumor necrosis factor alpha, interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor antagonist, and IL-6, as well as soluble receptors of tumor necrosis factor and IL-6 (sIL-6R) in serum of Gambian children with cerebral malaria, mild or asymptomatic malaria, or other illnesses unrelated to malaria. Because cytokine secretion may be triggered by toxic structures containing phosphatidylinositol (PI), we also measured concentrations of anti-PI antibodies and the PI-binding serum protein beta-2-glycoprotein I. We found increased concentrations of IL-6, sIL-6R, IL-1ra, and some immunoglobulin M antibodies against PI in children with cerebral malaria, but those who died had decreased concentrations of beta-2-glycoprotein I. We conclude that increased concentrations of cytokines and soluble cytokine receptors represent a normal host response to P. falciparum infections but that excessive secretion of cytokines like IL-6 may predispose to cerebral malaria and a fatal outcome while beta-2-glycoprotein I may protect against a fatal outcome of cerebral malaria.
M3 - Journal article
C2 - 7927698
VL - 62
SP - 4374
EP - 4379
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 10
ER -
ID: 18106897