TY - JOUR

T1 - Incidence and survival of hypopharyngeal cancer

T2 - a Danish Nation-Wide Study from 1980 to 2014

AU - Jakobsen, Kathrine Kronberg

AU - Wingstrand, Vibe Lindeblad

AU - Jensen, Jakob Schmidt

AU - Grønhøj, Christian

AU - Jensen, David Hebbelstrup

AU - Karnov, Kirstine

AU - Agander, Tina Klitmøller

AU - Specht, Lena

AU - von Buchwald, Christian

PY - 2019

Y1 - 2019

N2 - Objectives: To evaluate changes in incidence and survival of patients diagnosed with hypopharyngeal cancer (HPC) in Denmark in the period 1980-2014.Methods: All patients registered with HPC in the Danish Cancer Registry (DCR) in the period 1980-2014 were included. Age-adjusted incidence rates (AAIRs), average annual percentage change in incidence, and overall survival were calculated.Results: Two thousand and nine patients were included (79.7% men). The overall AAIR increased significantly from 0.3 per 100,000 to 1.1 per 100,000 during the study period, corresponding to an increase of 4.1% per year. The most frequent histology was squamous cell carcinoma (SCC) comprising 90.3%. The overall five-year survival increased with 13.5 percentage points from 13.4% in the period 1980-1985 to 26.9% in the period 2010-2014. Women demonstrated better survival compared to men with a hazard ratio of 0.83, and patients with SCC had better survival compared to the remaining histology groups.Conclusions: This nation-wide study, covering nearly four decades, showed a significant increase in incidence and survival of HPC in Denmark.

AB - Objectives: To evaluate changes in incidence and survival of patients diagnosed with hypopharyngeal cancer (HPC) in Denmark in the period 1980-2014.Methods: All patients registered with HPC in the Danish Cancer Registry (DCR) in the period 1980-2014 were included. Age-adjusted incidence rates (AAIRs), average annual percentage change in incidence, and overall survival were calculated.Results: Two thousand and nine patients were included (79.7% men). The overall AAIR increased significantly from 0.3 per 100,000 to 1.1 per 100,000 during the study period, corresponding to an increase of 4.1% per year. The most frequent histology was squamous cell carcinoma (SCC) comprising 90.3%. The overall five-year survival increased with 13.5 percentage points from 13.4% in the period 1980-1985 to 26.9% in the period 2010-2014. Women demonstrated better survival compared to men with a hazard ratio of 0.83, and patients with SCC had better survival compared to the remaining histology groups.Conclusions: This nation-wide study, covering nearly four decades, showed a significant increase in incidence and survival of HPC in Denmark.

U2 - 10.1080/0284186X.2019.1657585

DO - 10.1080/0284186X.2019.1657585

M3 - Journal article

C2 - 31505992

VL - 58

SP - 1570

EP - 1576

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 11

ER -