In vivo characterization of pustules in Malassezia Folliculitis by reflectance confocal microscopy and optical coherence tomography: A case series study
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In vivo characterization of pustules in Malassezia Folliculitis by reflectance confocal microscopy and optical coherence tomography : A case series study. / Andersen, A J B; Fuchs, C; Ardigo, M; Haedersdal, M; Mogensen, M.
I: Skin Research and Technology, Bind 24, Nr. 4, 2018, s. 535-541.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - In vivo characterization of pustules in Malassezia Folliculitis by reflectance confocal microscopy and optical coherence tomography
T2 - A case series study
AU - Andersen, A J B
AU - Fuchs, C
AU - Ardigo, M
AU - Haedersdal, M
AU - Mogensen, M
N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2018
Y1 - 2018
N2 - BACKGROUND AND OBJECTIVE: Malassezia Folliculitis (MaF) is an inflammatory condition of hair follicles caused by Malassezia yeast. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are imaging technologies enabling in vivo visualization of superficial skin layers. This study explores morphology of pustules in MaF imaged by OCT and RCM.METHODS: Patients with microscopically verified MaF were included in this case series. Morphology was evaluated qualitatively with RCM and OCT, focusing on shape, border and content of selected pustules.RESULTS: Nine patients with MaF were included. Clinically, six patients presented monomorphic MaF with multiple superficial pustules, while three patients showed more polymorph MaF appearance. In total 13 pustules were investigated by RCM and OCT. In RCM images, pustules varied from having a well-defined border with homogenous content to ill-defined borders with heterogeneous content. A distinct black halo was occasionally observed around pustules as were dilated vessels. In OCT images, pustules appeared polymorphic, showing both well- and ill-defined structures with oval or irregular shape and more or less homogenous content. Malassezia fungi were not discernible by either RCM or OCT. Specific morphological image features in RCM and OCT did not reflect different clinical manifestations of MaF.CONCLUSION: RCM and OCT images identify morphological aspects of MaF pustules, and confirm that MaF is a folliculitis with clinical as well as morphological variance.
AB - BACKGROUND AND OBJECTIVE: Malassezia Folliculitis (MaF) is an inflammatory condition of hair follicles caused by Malassezia yeast. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are imaging technologies enabling in vivo visualization of superficial skin layers. This study explores morphology of pustules in MaF imaged by OCT and RCM.METHODS: Patients with microscopically verified MaF were included in this case series. Morphology was evaluated qualitatively with RCM and OCT, focusing on shape, border and content of selected pustules.RESULTS: Nine patients with MaF were included. Clinically, six patients presented monomorphic MaF with multiple superficial pustules, while three patients showed more polymorph MaF appearance. In total 13 pustules were investigated by RCM and OCT. In RCM images, pustules varied from having a well-defined border with homogenous content to ill-defined borders with heterogeneous content. A distinct black halo was occasionally observed around pustules as were dilated vessels. In OCT images, pustules appeared polymorphic, showing both well- and ill-defined structures with oval or irregular shape and more or less homogenous content. Malassezia fungi were not discernible by either RCM or OCT. Specific morphological image features in RCM and OCT did not reflect different clinical manifestations of MaF.CONCLUSION: RCM and OCT images identify morphological aspects of MaF pustules, and confirm that MaF is a folliculitis with clinical as well as morphological variance.
KW - Adolescent
KW - Adult
KW - Aged
KW - Dermatomycoses/diagnostic imaging
KW - Female
KW - Folliculitis/diagnostic imaging
KW - Humans
KW - Malassezia
KW - Male
KW - Microscopy, Confocal
KW - Middle Aged
KW - Tomography, Optical Coherence
KW - Young Adult
U2 - 10.1111/srt.12463
DO - 10.1111/srt.12463
M3 - Journal article
C2 - 29484711
VL - 24
SP - 535
EP - 541
JO - Skin Research and Technology
JF - Skin Research and Technology
SN - 0909-752X
IS - 4
ER -
ID: 218088937