In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

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Standard

In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens. / Bygbjerg, I C; Theander, T G; Andersen, B J; Flachs, H; Jepsen, S; Larsen, P B.

I: Tropical Medicine and Parasitology, Bind 37, Nr. 3, 1986, s. 245-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bygbjerg, IC, Theander, TG, Andersen, BJ, Flachs, H, Jepsen, S & Larsen, PB 1986, 'In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens', Tropical Medicine and Parasitology, bind 37, nr. 3, s. 245-7.

APA

Bygbjerg, I. C., Theander, T. G., Andersen, B. J., Flachs, H., Jepsen, S., & Larsen, P. B. (1986). In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens. Tropical Medicine and Parasitology, 37(3), 245-7.

Vancouver

Bygbjerg IC, Theander TG, Andersen BJ, Flachs H, Jepsen S, Larsen PB. In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens. Tropical Medicine and Parasitology. 1986;37(3):245-7.

Author

Bygbjerg, I C ; Theander, T G ; Andersen, B J ; Flachs, H ; Jepsen, S ; Larsen, P B. / In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens. I: Tropical Medicine and Parasitology. 1986 ; Bind 37, Nr. 3. s. 245-7.

Bibtex

@article{548dd220a0dd11dd86a6000ea68e967b,

title = "In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens",

abstract = "The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.",

author = "Bygbjerg, {I C} and Theander, {T G} and Andersen, {B J} and H Flachs and S Jepsen and Larsen, {P B}",

note = "Keywords: Adult; Antigens, Fungal; Antigens, Protozoan; Candida albicans; Chloroquine; Humans; Lymphocyte Activation; Mefloquine; Mitogens; Plasmodium falciparum; Quinine; Quinolines; Tuberculin",

year = "1986",

language = "English",

volume = "37",

pages = "245--7",

journal = "Tropical Medicine and Parasitology",

issn = "0177-2392",

publisher = "Wiley-Blackwell",

number = "3",

}

RIS

TY - JOUR

T1 - In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

AU - Bygbjerg, I C

AU - Theander, T G

AU - Andersen, B J

AU - Flachs, H

AU - Jepsen, S

AU - Larsen, P B

N1 - Keywords: Adult; Antigens, Fungal; Antigens, Protozoan; Candida albicans; Chloroquine; Humans; Lymphocyte Activation; Mefloquine; Mitogens; Plasmodium falciparum; Quinine; Quinolines; Tuberculin

PY - 1986

Y1 - 1986

N2 - The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.

AB - The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.

M3 - Journal article

C2 - 3538350

VL - 37

SP - 245

EP - 247

JO - Tropical Medicine and Parasitology

JF - Tropical Medicine and Parasitology

SN - 0177-2392

IS - 3

ER -

ID: 6767226