Improvement in indices of cellular protection after psychological treatment for social anxiety disorder
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Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. / Månsson, Kristoffer N.T.; Lindqvist, Daniel; Yang, Liu L.; Svanborg, Cecilia; Isung, Josef; Nilsonne, Gustav; Bergman-Nordgren, Lise; El Alaoui, Samir; Hedman-Lagerlöf, Erik; Kraepelien, Martin; Högström, Jens; Andersson, Gerhard; Boraxbekk, Carl Johan; Fischer, Håkan; Lavebratt, Catharina; Wolkowitz, Owen M.; Furmark, Tomas.
I: Translational Psychiatry, Bind 9, Nr. 1, 340, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Improvement in indices of cellular protection after psychological treatment for social anxiety disorder
AU - Månsson, Kristoffer N.T.
AU - Lindqvist, Daniel
AU - Yang, Liu L.
AU - Svanborg, Cecilia
AU - Isung, Josef
AU - Nilsonne, Gustav
AU - Bergman-Nordgren, Lise
AU - El Alaoui, Samir
AU - Hedman-Lagerlöf, Erik
AU - Kraepelien, Martin
AU - Högström, Jens
AU - Andersson, Gerhard
AU - Boraxbekk, Carl Johan
AU - Fischer, Håkan
AU - Lavebratt, Catharina
AU - Wolkowitz, Owen M.
AU - Furmark, Tomas
N1 - Publisher Copyright: © 2019, The Author(s).
PY - 2019
Y1 - 2019
N2 - Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.
AB - Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen’s d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.
U2 - 10.1038/s41398-019-0668-2
DO - 10.1038/s41398-019-0668-2
M3 - Journal article
C2 - 31852887
AN - SCOPUS:85076880962
VL - 9
JO - Translational Psychiatry
JF - Translational Psychiatry
SN - 2158-3188
IS - 1
M1 - 340
ER -
ID: 332185213