Impact of p16-overexpression on overall and progression-free survival outcomes in oral cavity squamous cell carcinomas: A semi-national, population-based study
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Impact of p16-overexpression on overall and progression-free survival outcomes in oral cavity squamous cell carcinomas: A semi-national, population-based study. / Schneider, Katrine; Jakobsen, Kathrine K.; Jensen, Jakob S.; Wessel, Irene; Christensen, Anders; Specht, Lena; Lelkaitis, Giedrius; Mirian, Christian; Buchwald, Christian V.; Grønhøj, Christian.
I: Oral Oncology, Bind 111, 105031, 01.12.2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Impact of p16-overexpression on overall and progression-free survival outcomes in oral cavity squamous cell carcinomas: A semi-national, population-based study
AU - Schneider, Katrine
AU - Jakobsen, Kathrine K.
AU - Jensen, Jakob S.
AU - Wessel, Irene
AU - Christensen, Anders
AU - Specht, Lena
AU - Lelkaitis, Giedrius
AU - Mirian, Christian
AU - Buchwald, Christian V.
AU - Grønhøj, Christian
PY - 2020/12/1
Y1 - 2020/12/1
N2 - ObjectivesHuman papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. Materials and methods: All patients diagnosed with OSCC in Eastern Denmark in the period 2008–2014 were enrolled. Survival estimates were evaluated as overall survival (OS) and progression free survival (PFS) by Kaplan-Meier survival curves and multivariate Cox-regression analyses. Results: We included 575 patients from which 13% (n = 69) had p16-positive tumors. The 5-year OS were 55% and 62% for the p16-negative and p16-positive patients, respectively, and the 5-year PFS were 48% and 50%. In a multivariate survival analysis, p16-positivity showed no significant influence on OS (HR: 1.06 [0.67–1.70], p = 0.79) and PFS (HR: 1.11 [0.76–1.63], p = 0.58). Conclusion: In this population-based cohort of non-selected OSCC patients, we found no difference in survival outcomes when stratified on p16-overexpression status.
AB - ObjectivesHuman papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. Materials and methods: All patients diagnosed with OSCC in Eastern Denmark in the period 2008–2014 were enrolled. Survival estimates were evaluated as overall survival (OS) and progression free survival (PFS) by Kaplan-Meier survival curves and multivariate Cox-regression analyses. Results: We included 575 patients from which 13% (n = 69) had p16-positive tumors. The 5-year OS were 55% and 62% for the p16-negative and p16-positive patients, respectively, and the 5-year PFS were 48% and 50%. In a multivariate survival analysis, p16-positivity showed no significant influence on OS (HR: 1.06 [0.67–1.70], p = 0.79) and PFS (HR: 1.11 [0.76–1.63], p = 0.58). Conclusion: In this population-based cohort of non-selected OSCC patients, we found no difference in survival outcomes when stratified on p16-overexpression status.
U2 - 10.1016/j.oraloncology.2020.105031
DO - 10.1016/j.oraloncology.2020.105031
M3 - Journal article
C2 - 33069060
VL - 111
JO - Oral Oncology Extra
JF - Oral Oncology Extra
SN - 1741-9409
M1 - 105031
ER -
ID: 260691005