Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
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Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development : a systematic review. / Bodhini, Dhanasekaran; Morton, Robert W; Santhakumar, Vanessa; Nakabuye, Mariam; Pomares-Millan, Hugo; Clemmensen, Christoffer; Fitzpatrick, Stephanie L; Guasch-Ferre, Marta; Pankow, James S; Ried-Larsen, Mathias; Franks, Paul W; Tobias, Deirdre K; Merino, Jordi; Mohan, Viswanathan; Loos, Ruth J F; ADA/EASD PMDI.
I: Communications Medicine, Bind 3, 133, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development
T2 - a systematic review
AU - Bodhini, Dhanasekaran
AU - Morton, Robert W
AU - Santhakumar, Vanessa
AU - Nakabuye, Mariam
AU - Pomares-Millan, Hugo
AU - Clemmensen, Christoffer
AU - Fitzpatrick, Stephanie L
AU - Guasch-Ferre, Marta
AU - Pankow, James S
AU - Ried-Larsen, Mathias
AU - Franks, Paul W
AU - Tobias, Deirdre K
AU - Merino, Jordi
AU - Mohan, Viswanathan
AU - Loos, Ruth J F
AU - ADA/EASD PMDI
N1 - © 2023. Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D.METHODS: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier.RESULTS: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition.CONCLUSIONS: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
AB - BACKGROUND: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D.METHODS: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier.RESULTS: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition.CONCLUSIONS: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
U2 - 10.1038/s43856-023-00363-0
DO - 10.1038/s43856-023-00363-0
M3 - Journal article
C2 - 37794109
VL - 3
JO - Communications Medicine
JF - Communications Medicine
SN - 2730-664X
M1 - 133
ER -
ID: 379089299