Impact of body composition changes on risk of all-cause mortality in older adults
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Impact of body composition changes on risk of all-cause mortality in older adults. / Graf, Christophe E; Herrmann, François R; Spoerri, Adrian; Makhlouf, Anne-Marie; Sørensen, Thorkild I A; Ho, Sylvain; Karsegard, Véronique L; Genton, Laurence.
I: Clinical Nutrition, Bind 35, Nr. 6, 12.2016, s. 1499-1505.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of body composition changes on risk of all-cause mortality in older adults
AU - Graf, Christophe E
AU - Herrmann, François R
AU - Spoerri, Adrian
AU - Makhlouf, Anne-Marie
AU - Sørensen, Thorkild I A
AU - Ho, Sylvain
AU - Karsegard, Véronique L
AU - Genton, Laurence
N1 - Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).CONCLUSIONS: FFMI loss is related to increased mortality in older persons.
AB - PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).CONCLUSIONS: FFMI loss is related to increased mortality in older persons.
U2 - 10.1016/j.clnu.2016.04.003
DO - 10.1016/j.clnu.2016.04.003
M3 - Journal article
C2 - 27126709
VL - 35
SP - 1499
EP - 1505
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 6
ER -
ID: 166944820