Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy. / Schoos, Ann-Marie Malby; Bullens, Dominique; Chawes, Bo Lund; Costa, Joana; De Vlieger, Liselot; DunnGalvin, Audrey; Epstein, Michelle M; Garssen, Johan; Hilger, Christiane; Knipping, Karen; Kuehn, Annette; Mijakoski, Dragan; Munblit, Daniel; Nekliudov, Nikita A; Ozdemir, Cevdet; Patient, Karine; Peroni, Diego; Stoleski, Sasho; Stylianou, Eva; Tukalj, Mirjana; Verhoeckx, Kitty; Zidarn, Mihaela; van de Veen, Willem.
I: Frontiers in Immunology, Bind 11, 568598, 2020.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
AU - Schoos, Ann-Marie Malby
AU - Bullens, Dominique
AU - Chawes, Bo Lund
AU - Costa, Joana
AU - De Vlieger, Liselot
AU - DunnGalvin, Audrey
AU - Epstein, Michelle M
AU - Garssen, Johan
AU - Hilger, Christiane
AU - Knipping, Karen
AU - Kuehn, Annette
AU - Mijakoski, Dragan
AU - Munblit, Daniel
AU - Nekliudov, Nikita A
AU - Ozdemir, Cevdet
AU - Patient, Karine
AU - Peroni, Diego
AU - Stoleski, Sasho
AU - Stylianou, Eva
AU - Tukalj, Mirjana
AU - Verhoeckx, Kitty
AU - Zidarn, Mihaela
AU - van de Veen, Willem
N1 - Copyright © 2020 Schoos, Bullens, Chawes, Costa, De Vlieger, DunnGalvin, Epstein, Garssen, Hilger, Knipping, Kuehn, Mijakoski, Munblit, Nekliudov, Ozdemir, Patient, Peroni, Stoleski, Stylianou, Tukalj, Verhoeckx, Zidarn and van de Veen.
PY - 2020
Y1 - 2020
N2 - IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.
AB - IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.
U2 - 10.3389/fimmu.2020.568598
DO - 10.3389/fimmu.2020.568598
M3 - Review
C2 - 33224138
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 568598
ER -
ID: 257328833