Immunohistochemical demonstration of a hitherto undescribed localization of hemoglobin A and F in endodermal cells of normal human yolk sac and endodermal sinus tumor.
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Immunohistochemical demonstration of a hitherto undescribed localization of hemoglobin A and F in endodermal cells of normal human yolk sac and endodermal sinus tumor. / Albrechtsen, R; Wewer, U; Wimberley, P D.
I: Acta pathologica et microbiologica Scandinavica. Section A, Pathology, Bind 88, Nr. 3, 1980, s. 175-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Immunohistochemical demonstration of a hitherto undescribed localization of hemoglobin A and F in endodermal cells of normal human yolk sac and endodermal sinus tumor.
AU - Albrechtsen, R
AU - Wewer, U
AU - Wimberley, P D
N1 - Keywords: Endoderm; Female; Fetal Hemoglobin; Hemoglobin A; Humans; Immunoenzyme Techniques; Male; Mesonephroma; Ovarian Neoplasms; Pregnancy; Testicular Neoplasms; Yolk Sac
PY - 1980
Y1 - 1980
N2 - In this study of 4 human yolk sacs, the presence of hemoglobin A and F (HbA and HbF) is demonstrated for the first time in epithelial cells (type 1) and erythroid-like cells (type 2) in the endodermal layer by immunoperoxidase technique. Our findings strongly support the hypothesis previously proposed that the red blood cells formed in the yolk sac are of endodermal origin. Tumor with yolk sac differentiation (8 endodermal sinus tumors and 1 embryonal carcinoma with vitelline areas) similarly showed HbA and HbF localisation in endodermal cells. None of 59 germ cell tumors of other types contained these hemoglobins in the neoplastic cells.
AB - In this study of 4 human yolk sacs, the presence of hemoglobin A and F (HbA and HbF) is demonstrated for the first time in epithelial cells (type 1) and erythroid-like cells (type 2) in the endodermal layer by immunoperoxidase technique. Our findings strongly support the hypothesis previously proposed that the red blood cells formed in the yolk sac are of endodermal origin. Tumor with yolk sac differentiation (8 endodermal sinus tumors and 1 embryonal carcinoma with vitelline areas) similarly showed HbA and HbF localisation in endodermal cells. None of 59 germ cell tumors of other types contained these hemoglobins in the neoplastic cells.
M3 - Journal article
C2 - 6155756
VL - 88
SP - 175
EP - 178
JO - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
JF - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
SN - 0365-4184
IS - 3
ER -
ID: 5237298