Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas : Review of the literature. / Saber, Camelia Nami; Grønhøj Larsen, Christian; Dalianis, Tina; Von Buchwald, Christian.

I: Oral Oncology, Bind 58, 07.2016, s. 8-13.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Saber, CN, Grønhøj Larsen, C, Dalianis, T & Von Buchwald, C 2016, 'Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature', Oral Oncology, bind 58, s. 8-13. https://doi.org/10.1016/j.oraloncology.2016.04.004

APA

Saber, C. N., Grønhøj Larsen, C., Dalianis, T., & Von Buchwald, C. (2016). Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature. Oral Oncology, 58, 8-13. https://doi.org/10.1016/j.oraloncology.2016.04.004

Vancouver

Saber CN, Grønhøj Larsen C, Dalianis T, Von Buchwald C. Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature. Oral Oncology. 2016 jul.;58:8-13. https://doi.org/10.1016/j.oraloncology.2016.04.004

Author

Saber, Camelia Nami ; Grønhøj Larsen, Christian ; Dalianis, Tina ; Von Buchwald, Christian. / Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas : Review of the literature. I: Oral Oncology. 2016 ; Bind 58. s. 8-13.

Bibtex

@article{3a72e6d396c049f5ad6c94a2b2ad00d8,
title = "Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature",
abstract = "Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.",
keywords = "HPV, Immunology, Oropharyngeal tumor",
author = "Saber, {Camelia Nami} and {Gr{\o}nh{\o}j Larsen}, Christian and Tina Dalianis and {Von Buchwald}, Christian",
year = "2016",
month = jul,
doi = "10.1016/j.oraloncology.2016.04.004",
language = "English",
volume = "58",
pages = "8--13",
journal = "Oral Oncology Extra",
issn = "1741-9409",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas

T2 - Review of the literature

AU - Saber, Camelia Nami

AU - Grønhøj Larsen, Christian

AU - Dalianis, Tina

AU - Von Buchwald, Christian

PY - 2016/7

Y1 - 2016/7

N2 - Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

AB - Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

KW - HPV

KW - Immunology

KW - Oropharyngeal tumor

U2 - 10.1016/j.oraloncology.2016.04.004

DO - 10.1016/j.oraloncology.2016.04.004

M3 - Review

C2 - 27311396

AN - SCOPUS:84965102773

VL - 58

SP - 8

EP - 13

JO - Oral Oncology Extra

JF - Oral Oncology Extra

SN - 1741-9409

ER -

ID: 180937905