Imaging the inflammatory phenotype in migraine
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We conducted a systematic review in the Pubmed and Embase databases to evaluate existing imaging data on inflammation in migraine, and to identify gaps in the literature. We included 20 studies investigating migraine without aura (N = 4), migraine with aura (N = 8), both migraine with and without aura (N = 3), or hemiplegic migraine (N = 5).
In migraine without aura, macrophage activation was not evident. In migraine with aura, imaging evidence suggested microglial and parameningeal inflammatory activity. Increased vascular permeability was mostly found in hemiplegic migraine, and was atypical in migraine with and without aura. Based on the weight of existing and emerging data, we show that most studies have concentrated on demonstrating increased vascular permeability as a marker of neuroinflammation, with tools that may not have been optimal. In the future, novel, more sensitive techniques, as well as imaging tracers delineating specific inflammatory pathways may further bridge the gap between preclinical and clinical findings.
Originalsprog | Engelsk |
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Artikelnummer | 60 |
Tidsskrift | Journal of Headache and Pain |
Vol/bind | 23 |
Udgave nummer | 1 |
Antal sider | 18 |
ISSN | 1129-2369 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Dr. Gollion reports personal fees for consultancy from Teva. Dr. Amin has received honoraria and personal fees from Teva, Lundbeck, Novartis, Eli Lilly for lecturing or participating in advisory boards. Dr. Hadjikhani received grant support from the National Institute of Healthy, grant NIH-NCCAM 5P01AT009965-03. Dr. Ashina has received personal fees from AbbVie/Allergan, Amgen, Eli Lilly, Lundbeck, Novartis and Teva Pharmaceuticals, and is the principal investigator of ongoing clinical trials for AbbVie/Allergan, Amgen, and Lundbeck. He has received research grants from the Lundbeck Foundation, Novo Nordisk Foundation, and Novartis. He is associate editor of Brain, Cephalalgia, and The Journal of Headache and Pain. He is past President of the International Headache Society. Dr. Moskowitz and Dr. Christensen have no disclosures to report.
Publisher Copyright:
© 2022, The Author(s).
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