IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood. / Gbaguidi, Mahugnon L Erasme; Adamou, Rafiou; Edslev, Sofie; Domingo, Nadia D; Dechavanne, Celia; Massougbodji, Achille; Garcia, André; Theisen, Michael; Milet, Jacqueline; Donadi, Eduardo A; Courtin, David; Hansen, Anita .
I: Malaria Journal, Bind 23, Nr. 1, 154, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood
AU - Gbaguidi, Mahugnon L Erasme
AU - Adamou, Rafiou
AU - Edslev, Sofie
AU - Domingo, Nadia D
AU - Dechavanne, Celia
AU - Massougbodji, Achille
AU - Garcia, André
AU - Theisen, Michael
AU - Milet, Jacqueline
AU - Donadi, Eduardo A
AU - Courtin, David
AU - Hansen, Anita
N1 - © 2024. The Author(s).
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Plasmodium falciparum malaria is a public health issue mostly seen in tropical countries. Until now, there is no effective malaria vaccine against antigens specific to the blood-stage of P. falciparum infection. Because the pathogenesis of malarial disease results from blood-stage infection, it is essential to identify the most promising blood-stage vaccine candidate antigens under natural exposure to malaria infection.METHODS: A cohort of 400 pregnant women and their infants was implemented in South Benin. An active and passive protocol of malaria surveillance was established during pregnancy and infancy to precisely ascertain malaria infections during the follow-up. Twenty-eight antibody (Ab) responses specific to seven malaria candidate vaccine antigens were repeatedly quantified during pregnancy (3 time points) and infancy (6 time points) in order to study the Ab kinetics and their protective role. Abs were quantified by ELISA and logistic, linear and cox-proportional hazard model were performed to analyse the associations between Ab responses and protection against malaria in mothers and infants, taking into account socio-economic factors and for infants an environmental risk of exposure.RESULTS: The levels of IgM against MSP1, MSP2 and MSP3 showed an early protective response against the onset of symptomatic malaria infections starting from the 18th month of life, whereas no association was found for IgG responses during infancy. In women, some IgG responses tend to be associated with a protection against malaria risk along pregnancy and at delivery, among them IgG3 against GLURP-R0 and IgG2 against MSP1.CONCLUSION: The main finding suggests that IgM should be considered in vaccine designs during infanthood. Investigation of the functional role played by IgM in malaria protection needs further attention.
AB - BACKGROUND: Plasmodium falciparum malaria is a public health issue mostly seen in tropical countries. Until now, there is no effective malaria vaccine against antigens specific to the blood-stage of P. falciparum infection. Because the pathogenesis of malarial disease results from blood-stage infection, it is essential to identify the most promising blood-stage vaccine candidate antigens under natural exposure to malaria infection.METHODS: A cohort of 400 pregnant women and their infants was implemented in South Benin. An active and passive protocol of malaria surveillance was established during pregnancy and infancy to precisely ascertain malaria infections during the follow-up. Twenty-eight antibody (Ab) responses specific to seven malaria candidate vaccine antigens were repeatedly quantified during pregnancy (3 time points) and infancy (6 time points) in order to study the Ab kinetics and their protective role. Abs were quantified by ELISA and logistic, linear and cox-proportional hazard model were performed to analyse the associations between Ab responses and protection against malaria in mothers and infants, taking into account socio-economic factors and for infants an environmental risk of exposure.RESULTS: The levels of IgM against MSP1, MSP2 and MSP3 showed an early protective response against the onset of symptomatic malaria infections starting from the 18th month of life, whereas no association was found for IgG responses during infancy. In women, some IgG responses tend to be associated with a protection against malaria risk along pregnancy and at delivery, among them IgG3 against GLURP-R0 and IgG2 against MSP1.CONCLUSION: The main finding suggests that IgM should be considered in vaccine designs during infanthood. Investigation of the functional role played by IgM in malaria protection needs further attention.
KW - Humans
KW - Female
KW - Plasmodium falciparum/immunology
KW - Malaria, Falciparum/prevention & control
KW - Pregnancy
KW - Infant
KW - Immunoglobulin M/blood
KW - Immunoglobulin G/blood
KW - Antibodies, Protozoan/blood
KW - Benin
KW - Antigens, Protozoan/immunology
KW - Adult
KW - Young Adult
KW - Enzyme-Linked Immunosorbent Assay
KW - Infant, Newborn
KW - Pregnancy Complications, Parasitic/prevention & control
KW - Cohort Studies
U2 - 10.1186/s12936-024-04970-7
DO - 10.1186/s12936-024-04970-7
M3 - Journal article
C2 - 38764069
VL - 23
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
IS - 1
M1 - 154
ER -
ID: 392398262