Identifying multiple tumor-specific epitopes from large-scale screening for overexpressed mRNA
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Identifying multiple tumor-specific epitopes from large-scale screening for overexpressed mRNA. / Buus, Søren; Claesson, Mogens Helweg.
I: Current Opinion in Immunology, Bind 16, Nr. 2, 2004, s. 137-42.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Identifying multiple tumor-specific epitopes from large-scale screening for overexpressed mRNA
AU - Buus, Søren
AU - Claesson, Mogens Helweg
N1 - Keywords: Epitopes, T-Lymphocyte; Humans; Immunotherapy; Major Histocompatibility Complex; RNA, Messenger; T-Lymphocytes, Cytotoxic
PY - 2004
Y1 - 2004
N2 - The rationale of a T-cell epitope-based approach to cancer treatment is primarily rooted in the hypothesis that CD8(+) cytotoxic T cells (CTLs) can be manipulated to specifically identify and kill cancer cells. A solid understanding of CTL specificity and activation is a fundamental requirement for tumor immunotherapy. The means to identify tumor-specific CTL epitopes and to monitor corresponding CTL responses are important enabling technologies. Recent advances in these enabling technologies include their ability to exploit genomic, transcriptomic and proteomic information. These advances constitute new opportunities, which will enable approaches to tumor immunotherapy that encompass both human diversity and tumor heterogeneity, increase the efficacy of tumor immunotherapy and potentially provide the opportunity for individualized therapy.
AB - The rationale of a T-cell epitope-based approach to cancer treatment is primarily rooted in the hypothesis that CD8(+) cytotoxic T cells (CTLs) can be manipulated to specifically identify and kill cancer cells. A solid understanding of CTL specificity and activation is a fundamental requirement for tumor immunotherapy. The means to identify tumor-specific CTL epitopes and to monitor corresponding CTL responses are important enabling technologies. Recent advances in these enabling technologies include their ability to exploit genomic, transcriptomic and proteomic information. These advances constitute new opportunities, which will enable approaches to tumor immunotherapy that encompass both human diversity and tumor heterogeneity, increase the efficacy of tumor immunotherapy and potentially provide the opportunity for individualized therapy.
U2 - 10.1016/j.coi.2004.02.004
DO - 10.1016/j.coi.2004.02.004
M3 - Journal article
C2 - 15023404
VL - 16
SP - 137
EP - 142
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 2
ER -
ID: 9943364