TY - JOUR

T1 - Identifying Gene-Environment Interactions in Schizophrenia

T2 - Contemporary Challenges for Integrated, Large-scale Investigations

AU - van Os, Jim

AU - Rutten, Bart P

AU - Myin-Germeys, Inez

AU - Delespaul, Philippe

AU - Viechtbauer, Wolfgang

AU - van Zelst, Catherine

AU - Bruggeman, Richard

AU - Reininghaus, Ulrich

AU - Morgan, Craig

AU - Murray, Robin M

AU - Di Forti, Marta

AU - McGuire, Philip

AU - Valmaggia, Lucia R

AU - Kempton, Matthew J

AU - Gayer-Anderson, Charlotte

AU - Hubbard, Kathryn

AU - Beards, Stephanie

AU - Stilo, Simona A

AU - Onyejiaka, Adanna

AU - Bourque, Francois

AU - Modinos, Gemma

AU - Tognin, Stefania

AU - Calem, Maria

AU - O'Donovan, Michael C

AU - Owen, Michael J

AU - Holmans, Peter

AU - Williams, Nigel

AU - Craddock, Nicholas

AU - Richards, Alexander

AU - Humphreys, Isla

AU - Meyer-Lindenberg, Andreas

AU - Leweke, F Markus

AU - Tost, Heike

AU - Akdeniz, Ceren

AU - Rohleder, Cathrin

AU - Bumb, J Malte

AU - Schwarz, Emanuel

AU - Alptekin, Köksal

AU - Üçok, Alp

AU - Saka, Meram Can

AU - Atbaşoğlu, E Cem

AU - Gülöksüz, Sinan

AU - Gumus-Akay, Guvem

AU - Cihan, Burçin

AU - Karadağ, Hasan

AU - Soygür, Haldan

AU - Cankurtaran, Eylem Şahin

AU - Ulusoy, Semra

AU - Akdede, Berna

AU - Nordentoft, Merete

AU - European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI)

N1 - © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2014/7

Y1 - 2014/7

N2 - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.

AB - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.

KW - Gene-Environment Interaction

KW - Genetic Predisposition to Disease

KW - Humans

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Social Environment

U2 - 10.1093/schbul/sbu069

DO - 10.1093/schbul/sbu069

M3 - Journal article

C2 - 24860087

VL - 40

SP - 729

EP - 736

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 4

ER -