Identification of the ClpX Regulon in Staphylococcus aureus
Publikation: Konferencebidrag › Poster › Forskning
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Identification of the ClpX Regulon in Staphylococcus aureus. / Jelsbak, Lotte; Thomsen, Line Elnif; Ingmer, Hanne; Donat, Stefanie; Ohlsen, Knut; Frees, Dorte.
2006. Poster session præsenteret ved ASM General Meeting, Orlando, Florida, USA.Publikation: Konferencebidrag › Poster › Forskning
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T1 - Identification of the ClpX Regulon in Staphylococcus aureus
AU - Jelsbak, Lotte
AU - Thomsen, Line Elnif
AU - Ingmer, Hanne
AU - Donat, Stefanie
AU - Ohlsen, Knut
AU - Frees, Dorte
N1 - Conference code: 106
PY - 2006
Y1 - 2006
N2 - Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.
AB - Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.
M3 - Poster
Y2 - 21 May 2006 through 25 May 2006
ER -
ID: 8031127