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Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. / Went, Molly; Sud, Amit; Försti, Asta; Halvarsson, Britt Marie; Weinhold, Niels; Kimber, Scott; van Duin, Mark; Thorleifsson, Gudmar; Holroyd, Amy; Johnson, David C.; Li, Ni; Orlando, Giulia; Law, Philip J.; Ali, Mina; Chen, Bowang; Mitchell, Jonathan S.; Gudbjartsson, Daniel F.; Kuiper, Rowan; Stephens, Owen W.; Bertsch, Uta; Broderick, Peter; Campo, Chiara; Bandapalli, Obul R.; Einsele, Hermann; Gregory, Walter A.; Gullberg, Urban; Hillengass, Jens; Hoffmann, Per; Jackson, Graham H.; Jöckel, Karl Heinz; Johnsson, Ellinor; Kristinsson, Sigurður Y.; Mellqvist, Ulf Henrik; Nahi, Hareth; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, ZSofia S.; Muir, Kenneth; Pashayan, Nora; Nickel, Jolanta; Nöthen, Markus M.; Vangsted, Annette; Andersen, Niels Frost; Nilsson, Björn; Nordestgaard, Børge G.; The Practical Consortium.
I:
Nature Communications, Bind 9, 3707, 13.09.2018.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Went, M, Sud, A, Försti, A, Halvarsson, BM, Weinhold, N, Kimber, S, van Duin, M, Thorleifsson, G, Holroyd, A, Johnson, DC, Li, N, Orlando, G, Law, PJ, Ali, M, Chen, B, Mitchell, JS, Gudbjartsson, DF, Kuiper, R, Stephens, OW, Bertsch, U, Broderick, P, Campo, C, Bandapalli, OR, Einsele, H, Gregory, WA, Gullberg, U, Hillengass, J, Hoffmann, P, Jackson, GH, Jöckel, KH, Johnsson, E, Kristinsson, SY, Mellqvist, UH, Nahi, H, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Swerdlow, A, Eeles, RA, Kote-Jarai, ZSS, Muir, K, Pashayan, N, Nickel, J, Nöthen, MM
, Vangsted, A, Andersen, NF, Nilsson, B
, Nordestgaard, BG & The Practical Consortium 2018, '
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma',
Nature Communications, bind 9, 3707.
https://doi.org/10.1038/s41467-018-04989-wAPA
Went, M., Sud, A., Försti, A., Halvarsson, B. M., Weinhold, N., Kimber, S., van Duin, M., Thorleifsson, G., Holroyd, A., Johnson, D. C., Li, N., Orlando, G., Law, P. J., Ali, M., Chen, B., Mitchell, J. S., Gudbjartsson, D. F., Kuiper, R., Stephens, O. W., ... The Practical Consortium (2018).
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Nature Communications,
9, [3707].
https://doi.org/10.1038/s41467-018-04989-wVancouver
Went M, Sud A, Försti A, Halvarsson BM, Weinhold N, Kimber S o.a.
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Nature Communications. 2018 sep. 13;9. 3707.
https://doi.org/10.1038/s41467-018-04989-wAuthor
Went, Molly ; Sud, Amit ; Försti, Asta ; Halvarsson, Britt Marie ; Weinhold, Niels ; Kimber, Scott ; van Duin, Mark ; Thorleifsson, Gudmar ; Holroyd, Amy ; Johnson, David C. ; Li, Ni ; Orlando, Giulia ; Law, Philip J. ; Ali, Mina ; Chen, Bowang ; Mitchell, Jonathan S. ; Gudbjartsson, Daniel F. ; Kuiper, Rowan ; Stephens, Owen W. ; Bertsch, Uta ; Broderick, Peter ; Campo, Chiara ; Bandapalli, Obul R. ; Einsele, Hermann ; Gregory, Walter A. ; Gullberg, Urban ; Hillengass, Jens ; Hoffmann, Per ; Jackson, Graham H. ; Jöckel, Karl Heinz ; Johnsson, Ellinor ; Kristinsson, Sigurður Y. ; Mellqvist, Ulf Henrik ; Nahi, Hareth ; Easton, Douglas ; Pharoah, Paul ; Dunning, Alison ; Peto, Julian ; Canzian, Federico ; Swerdlow, Anthony ; Eeles, Rosalind A. ; Kote-Jarai, ZSofia S. ; Muir, Kenneth ; Pashayan, Nora ; Nickel, Jolanta ; Nöthen, Markus M. ; Vangsted, Annette ; Andersen, Niels Frost ; Nilsson, Björn ; Nordestgaard, Børge G. ; The Practical Consortium. / Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. I: Nature Communications. 2018 ; Bind 9.
Bibtex
@article{bcfc7cacf928415e8b03ff9ac2c62d5e,
title = "Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma",
abstract = "Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM.",
author = "Molly Went and Amit Sud and Asta F{\"o}rsti and Halvarsson, {Britt Marie} and Niels Weinhold and Scott Kimber and {van Duin}, Mark and Gudmar Thorleifsson and Amy Holroyd and Johnson, {David C.} and Ni Li and Giulia Orlando and Law, {Philip J.} and Mina Ali and Bowang Chen and Mitchell, {Jonathan S.} and Gudbjartsson, {Daniel F.} and Rowan Kuiper and Stephens, {Owen W.} and Uta Bertsch and Peter Broderick and Chiara Campo and Bandapalli, {Obul R.} and Hermann Einsele and Gregory, {Walter A.} and Urban Gullberg and Jens Hillengass and Per Hoffmann and Jackson, {Graham H.} and J{\"o}ckel, {Karl Heinz} and Ellinor Johnsson and Kristinsson, {Sigur{\dh}ur Y.} and Mellqvist, {Ulf Henrik} and Hareth Nahi and Douglas Easton and Paul Pharoah and Alison Dunning and Julian Peto and Federico Canzian and Anthony Swerdlow and Eeles, {Rosalind A.} and Kote-Jarai, {ZSofia S.} and Kenneth Muir and Nora Pashayan and Jolanta Nickel and N{\"o}then, {Markus M.} and Annette Vangsted and Andersen, {Niels Frost} and Bj{\"o}rn Nilsson and Nordestgaard, {B{\o}rge G.} and {The Practical Consortium}",
year = "2018",
month = sep,
day = "13",
doi = "10.1038/s41467-018-04989-w",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
AU - Went, Molly
AU - Sud, Amit
AU - Försti, Asta
AU - Halvarsson, Britt Marie
AU - Weinhold, Niels
AU - Kimber, Scott
AU - van Duin, Mark
AU - Thorleifsson, Gudmar
AU - Holroyd, Amy
AU - Johnson, David C.
AU - Li, Ni
AU - Orlando, Giulia
AU - Law, Philip J.
AU - Ali, Mina
AU - Chen, Bowang
AU - Mitchell, Jonathan S.
AU - Gudbjartsson, Daniel F.
AU - Kuiper, Rowan
AU - Stephens, Owen W.
AU - Bertsch, Uta
AU - Broderick, Peter
AU - Campo, Chiara
AU - Bandapalli, Obul R.
AU - Einsele, Hermann
AU - Gregory, Walter A.
AU - Gullberg, Urban
AU - Hillengass, Jens
AU - Hoffmann, Per
AU - Jackson, Graham H.
AU - Jöckel, Karl Heinz
AU - Johnsson, Ellinor
AU - Kristinsson, Sigurður Y.
AU - Mellqvist, Ulf Henrik
AU - Nahi, Hareth
AU - Easton, Douglas
AU - Pharoah, Paul
AU - Dunning, Alison
AU - Peto, Julian
AU - Canzian, Federico
AU - Swerdlow, Anthony
AU - Eeles, Rosalind A.
AU - Kote-Jarai, ZSofia S.
AU - Muir, Kenneth
AU - Pashayan, Nora
AU - Nickel, Jolanta
AU - Nöthen, Markus M.
AU - Vangsted, Annette
AU - Andersen, Niels Frost
AU - Nilsson, Björn
AU - Nordestgaard, Børge G.
AU - The Practical Consortium
PY - 2018/9/13
Y1 - 2018/9/13
N2 - Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM.
AB - Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM.
U2 - 10.1038/s41467-018-04989-w
DO - 10.1038/s41467-018-04989-w
M3 - Journal article
C2 - 30213928
AN - SCOPUS:85053336514
VL - 9
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 3707
ER -
