Identification of common genetic risk variants for autism spectrum disorder
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Identification of common genetic risk variants for autism spectrum disorder. / Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium.
I: Nature Genetics, Bind 51, Nr. 3, 03.2019, s. 431-444.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Identification of common genetic risk variants for autism spectrum disorder
AU - Grove, Jakob
AU - Ripke, Stephan
AU - Als, Thomas D
AU - Mattheisen, Manuel
AU - Walters, Raymond K
AU - Won, Hyejung
AU - Pallesen, Jonatan
AU - Agerbo, Esben
AU - Andreassen, Ole A
AU - Anney, Richard
AU - Awashti, Swapnil
AU - Belliveau, Rich
AU - Bettella, Francesco
AU - Buxbaum, Joseph D
AU - Bybjerg-Grauholm, Jonas
AU - Bækvad-Hansen, Marie
AU - Cerrato, Felecia
AU - Chambert, Kimberly
AU - Christensen, Jane H
AU - Churchhouse, Claire
AU - Dellenvall, Karin
AU - Demontis, Ditte
AU - De Rubeis, Silvia
AU - Devlin, Bernie
AU - Djurovic, Srdjan
AU - Dumont, Ashley L
AU - Goldstein, Jacqueline I
AU - Hansen, Christine S
AU - Hauberg, Mads Engel
AU - Hollegaard, Mads V
AU - Hope, Sigrun
AU - Howrigan, Daniel P
AU - Huang, Hailiang
AU - Hultman, Christina M
AU - Klei, Lambertus
AU - Maller, Julian
AU - Martin, Joanna
AU - Martin, Alicia R
AU - Moran, Jennifer L
AU - Nyegaard, Mette
AU - Nærland, Terje
AU - Palmer, Duncan S
AU - Palotie, Aarno
AU - Pedersen, Carsten Bøcker
AU - Pedersen, Marianne Giørtz
AU - dPoterba, Timothy
AU - Poulsen, Jesper Buchhave
AU - Pourcain, Beate St
AU - Nordentoft, Merete
AU - Werge, Thomas
AU - Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium
PY - 2019/3
Y1 - 2019/3
N2 - Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.
AB - Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.
KW - Adolescent
KW - Autism Spectrum Disorder/genetics
KW - Case-Control Studies
KW - Child
KW - Child, Preschool
KW - Denmark
KW - Female
KW - Genetic Predisposition to Disease/genetics
KW - Genome-Wide Association Study/methods
KW - Humans
KW - Male
KW - Multifactorial Inheritance/genetics
KW - Phenotype
KW - Polymorphism, Single Nucleotide/genetics
KW - Risk Factors
U2 - 10.1038/s41588-019-0344-8
DO - 10.1038/s41588-019-0344-8
M3 - Journal article
C2 - 30804558
VL - 51
SP - 431
EP - 444
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 3
ER -
ID: 232647121