Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Hypoglycaemia, cardiovascular disease, and mortality in diabetes : epidemiology, pathogenesis, and management. / Amiel, Stephanie A.; Aschner, Pablo; Childs, Belinda; Cryer, Philip E.; de Galan, Bastiaan E.; Frier, Brian M.; Gonder-Frederick, Linda; Heller, Simon R.; Jones, Timothy; Khunti, Kamlesh; Leiter, Lawrence A.; Luo, Yingying; McCrimmon, Rory J.; Pedersen-Bjergaard, Ulrik; Seaquist, Elizabeth R.; Zoungas, Sophia; The International Hypoglycaemia Study Group.

I: The Lancet Diabetes and Endocrinology, Bind 7, Nr. 5, 05.2019, s. 385-396.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Amiel, SA, Aschner, P, Childs, B, Cryer, PE, de Galan, BE, Frier, BM, Gonder-Frederick, L, Heller, SR, Jones, T, Khunti, K, Leiter, LA, Luo, Y, McCrimmon, RJ, Pedersen-Bjergaard, U, Seaquist, ER, Zoungas, S & The International Hypoglycaemia Study Group 2019, 'Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management', The Lancet Diabetes and Endocrinology, bind 7, nr. 5, s. 385-396. https://doi.org/10.1016/S2213-8587(18)30315-2

APA

Amiel, S. A., Aschner, P., Childs, B., Cryer, P. E., de Galan, B. E., Frier, B. M., Gonder-Frederick, L., Heller, S. R., Jones, T., Khunti, K., Leiter, L. A., Luo, Y., McCrimmon, R. J., Pedersen-Bjergaard, U., Seaquist, E. R., Zoungas, S., & The International Hypoglycaemia Study Group (2019). Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management. The Lancet Diabetes and Endocrinology, 7(5), 385-396. https://doi.org/10.1016/S2213-8587(18)30315-2

Vancouver

Amiel SA, Aschner P, Childs B, Cryer PE, de Galan BE, Frier BM o.a. Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management. The Lancet Diabetes and Endocrinology. 2019 maj;7(5):385-396. https://doi.org/10.1016/S2213-8587(18)30315-2

Author

Amiel, Stephanie A. ; Aschner, Pablo ; Childs, Belinda ; Cryer, Philip E. ; de Galan, Bastiaan E. ; Frier, Brian M. ; Gonder-Frederick, Linda ; Heller, Simon R. ; Jones, Timothy ; Khunti, Kamlesh ; Leiter, Lawrence A. ; Luo, Yingying ; McCrimmon, Rory J. ; Pedersen-Bjergaard, Ulrik ; Seaquist, Elizabeth R. ; Zoungas, Sophia ; The International Hypoglycaemia Study Group. / Hypoglycaemia, cardiovascular disease, and mortality in diabetes : epidemiology, pathogenesis, and management. I: The Lancet Diabetes and Endocrinology. 2019 ; Bind 7, Nr. 5. s. 385-396.

Bibtex

@article{425c3bd9933e46608eabbf6080fe82be,
title = "Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management",
abstract = "Hypoglycaemia has long been recognised as a dangerous side-effect of treatment of diabetes with insulin or insulin secretagogues. With its potential to disrupt cerebral function, hypoglycaemia can have a major effect on peoples' lives. Study findings have suggested that hypoglycaemia is associated with an increased risk of cardiovascular events and mortality. Different mechanisms by which hypoglycaemia might provoke cardiovascular events have been identified in experimental studies, and in clinical studies cardiac arrhythmias have been reported to be induced by hypoglycaemia, with one report describing sudden death during a severe episode. Emerging evidence suggests that the association between hypoglycaemia and cardiovascular events and mortality is likely to be multifactorial. The association is probably partly caused by confounding, with hypoglycaemia occurring more frequently in people with comorbidities who are also more likely to die than those without. However, people with type 1 or type 2 diabetes also seem at risk of hypoglycaemia-induced cardiovascular effects. This risk should be recognised by clinicians when agreeing glycaemic goals with patients and choosing appropriate glucose-lowering therapies.",
author = "Amiel, {Stephanie A.} and Pablo Aschner and Belinda Childs and Cryer, {Philip E.} and {de Galan}, {Bastiaan E.} and Frier, {Brian M.} and Linda Gonder-Frederick and Heller, {Simon R.} and Timothy Jones and Kamlesh Khunti and Leiter, {Lawrence A.} and Yingying Luo and McCrimmon, {Rory J.} and Ulrik Pedersen-Bjergaard and Seaquist, {Elizabeth R.} and Sophia Zoungas and {The International Hypoglycaemia Study Group}",
year = "2019",
month = may,
doi = "10.1016/S2213-8587(18)30315-2",
language = "English",
volume = "7",
pages = "385--396",
journal = "The Lancet Diabetes & Endocrinology",
issn = "2213-8587",
publisher = "The Lancet Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Hypoglycaemia, cardiovascular disease, and mortality in diabetes

T2 - epidemiology, pathogenesis, and management

AU - Amiel, Stephanie A.

AU - Aschner, Pablo

AU - Childs, Belinda

AU - Cryer, Philip E.

AU - de Galan, Bastiaan E.

AU - Frier, Brian M.

AU - Gonder-Frederick, Linda

AU - Heller, Simon R.

AU - Jones, Timothy

AU - Khunti, Kamlesh

AU - Leiter, Lawrence A.

AU - Luo, Yingying

AU - McCrimmon, Rory J.

AU - Pedersen-Bjergaard, Ulrik

AU - Seaquist, Elizabeth R.

AU - Zoungas, Sophia

AU - The International Hypoglycaemia Study Group

PY - 2019/5

Y1 - 2019/5

N2 - Hypoglycaemia has long been recognised as a dangerous side-effect of treatment of diabetes with insulin or insulin secretagogues. With its potential to disrupt cerebral function, hypoglycaemia can have a major effect on peoples' lives. Study findings have suggested that hypoglycaemia is associated with an increased risk of cardiovascular events and mortality. Different mechanisms by which hypoglycaemia might provoke cardiovascular events have been identified in experimental studies, and in clinical studies cardiac arrhythmias have been reported to be induced by hypoglycaemia, with one report describing sudden death during a severe episode. Emerging evidence suggests that the association between hypoglycaemia and cardiovascular events and mortality is likely to be multifactorial. The association is probably partly caused by confounding, with hypoglycaemia occurring more frequently in people with comorbidities who are also more likely to die than those without. However, people with type 1 or type 2 diabetes also seem at risk of hypoglycaemia-induced cardiovascular effects. This risk should be recognised by clinicians when agreeing glycaemic goals with patients and choosing appropriate glucose-lowering therapies.

AB - Hypoglycaemia has long been recognised as a dangerous side-effect of treatment of diabetes with insulin or insulin secretagogues. With its potential to disrupt cerebral function, hypoglycaemia can have a major effect on peoples' lives. Study findings have suggested that hypoglycaemia is associated with an increased risk of cardiovascular events and mortality. Different mechanisms by which hypoglycaemia might provoke cardiovascular events have been identified in experimental studies, and in clinical studies cardiac arrhythmias have been reported to be induced by hypoglycaemia, with one report describing sudden death during a severe episode. Emerging evidence suggests that the association between hypoglycaemia and cardiovascular events and mortality is likely to be multifactorial. The association is probably partly caused by confounding, with hypoglycaemia occurring more frequently in people with comorbidities who are also more likely to die than those without. However, people with type 1 or type 2 diabetes also seem at risk of hypoglycaemia-induced cardiovascular effects. This risk should be recognised by clinicians when agreeing glycaemic goals with patients and choosing appropriate glucose-lowering therapies.

U2 - 10.1016/S2213-8587(18)30315-2

DO - 10.1016/S2213-8587(18)30315-2

M3 - Review

C2 - 30926258

AN - SCOPUS:85064317136

VL - 7

SP - 385

EP - 396

JO - The Lancet Diabetes & Endocrinology

JF - The Lancet Diabetes & Endocrinology

SN - 2213-8587

IS - 5

ER -

ID: 240584955