Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses : An imaging finding or a complication? / Ahmad, Yousif; Makkar, Raj; Sondergaard, Lars.
I: Progress in Cardiovascular Diseases, Bind 72, 2022, s. 78-83.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses
T2 - An imaging finding or a complication?
AU - Ahmad, Yousif
AU - Makkar, Raj
AU - Sondergaard, Lars
N1 - Publisher Copyright: © 2022 Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - Transcatheter aortic valve implantation is a safe and effective therapy for patients with symptomatic severe aortic stenosis, with randomized data demonstrating outcomes at least equivalent to surgical aortic valve replacement across the spectrum of surgical risk. There has been substantial recent interest in the occurrence of hypoattenuated leaflet thickening and reduced leaflet motion, which are imaging features detected on computed tomography of patients who have received aortic bioprostheses. These phenomena may represent subclinical leaflet thrombosis with theoretical potential downstream effects on valve durability or thrombotic complications in the form of stroke. This review will discuss definitions, predictors, mechanisms, diagnosis, and natural history. We will also examine the frequency with which hypoattenuated leaflet thickening and reduced leaflet motion occur after both transcatheter and surgical aortic bioprostheses, and the clinical implications and potential impact on valve function, as well as strategies for prophylaxis and treatment.
AB - Transcatheter aortic valve implantation is a safe and effective therapy for patients with symptomatic severe aortic stenosis, with randomized data demonstrating outcomes at least equivalent to surgical aortic valve replacement across the spectrum of surgical risk. There has been substantial recent interest in the occurrence of hypoattenuated leaflet thickening and reduced leaflet motion, which are imaging features detected on computed tomography of patients who have received aortic bioprostheses. These phenomena may represent subclinical leaflet thrombosis with theoretical potential downstream effects on valve durability or thrombotic complications in the form of stroke. This review will discuss definitions, predictors, mechanisms, diagnosis, and natural history. We will also examine the frequency with which hypoattenuated leaflet thickening and reduced leaflet motion occur after both transcatheter and surgical aortic bioprostheses, and the clinical implications and potential impact on valve function, as well as strategies for prophylaxis and treatment.
KW - Aortic stenosis
KW - Leaflet thickening
KW - Transcatheter aortic valve implantation
U2 - 10.1016/j.pcad.2022.05.007
DO - 10.1016/j.pcad.2022.05.007
M3 - Review
C2 - 35675882
AN - SCOPUS:85133329666
VL - 72
SP - 78
EP - 83
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
SN - 0033-0620
ER -
ID: 329245027