Human Malformed Perinatal Anthropological Crania Contribute to New Insight in the Extension of Bone Malformations in Cranial Development
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Human Malformed Perinatal Anthropological Crania Contribute to New Insight in the Extension of Bone Malformations in Cranial Development. / Kjær, Inger; Marin, Amberley; Meyer, Ion.
I: Fetal and Pediatric Pathology, 2024, s. 1-13.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Human Malformed Perinatal Anthropological Crania Contribute to New Insight in the Extension of Bone Malformations in Cranial Development
AU - Kjær, Inger
AU - Marin, Amberley
AU - Meyer, Ion
PY - 2024
Y1 - 2024
N2 - IntroductionWe describe five abnormal crania which may provide more diagnostic data for assessment of abnormal crania in newborns.MethodsFive malformed perinatal crania from the Saxtorphian Collection are described using published prenatal abnormal cranial development criteria. These malformations were compared to normal cranial development arising from the migration of neural crest cells. Visual and photographic investigations were performed.ResultsThe malformed crania were occipital encephalocele, holoprosencephaly, anencephaly, and two without a recognizable diagnosis. The anthropological crania were malformed in the same regions as formerly observed in fetal pathology. These regions were comparable to fields formed during normal cell migration from the neural crest. This has seemingly not previously been demonstrated. One undiagnosed cranium may represent a Treacher Collins syndrome (Case 3). The other undiagnosed cranium (Case 4) could be from a scaphocephalic specimen.DiscussionSharp borderlines between malformed and non-malformed regions in cranial syndromes may enable improvement in diagnostics.
AB - IntroductionWe describe five abnormal crania which may provide more diagnostic data for assessment of abnormal crania in newborns.MethodsFive malformed perinatal crania from the Saxtorphian Collection are described using published prenatal abnormal cranial development criteria. These malformations were compared to normal cranial development arising from the migration of neural crest cells. Visual and photographic investigations were performed.ResultsThe malformed crania were occipital encephalocele, holoprosencephaly, anencephaly, and two without a recognizable diagnosis. The anthropological crania were malformed in the same regions as formerly observed in fetal pathology. These regions were comparable to fields formed during normal cell migration from the neural crest. This has seemingly not previously been demonstrated. One undiagnosed cranium may represent a Treacher Collins syndrome (Case 3). The other undiagnosed cranium (Case 4) could be from a scaphocephalic specimen.DiscussionSharp borderlines between malformed and non-malformed regions in cranial syndromes may enable improvement in diagnostics.
U2 - 10.1080/15513815.2024.2338434
DO - 10.1080/15513815.2024.2338434
M3 - Journal article
C2 - 38817107
SP - 1
EP - 13
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
SN - 1551-3815
ER -
ID: 393264253