TY - JOUR

T1 - Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse. VI. Effects of short term castration

AU - Kjaer, K

AU - Kirkeby, S

AU - Blecher, S R

N1 - Keywords: Animals; Castration; Enzyme Induction; Epididymis; Esterases; Male; Mice; Testosterone; Time Factors

PY - 1983

Y1 - 1983

N2 - The regional histology and esterase activity of the mouse epididymis after 24, 48, and 72 hr castration is reported. Differential sensitivity to androgen deprivation among the various epithelial cell types is described, allowing of positive identification of the cell types previously observed to survive long-term castration. The possibility of an androgen binding protein, as described in the rat and rabbit, is suggested on morphological grounds. The epididymal body appears to contain a class of highly androgen sensitive cells that degenerate rapidly following castration and a second class that survive from which regeneration occurs on testosterone replacement.

AB - The regional histology and esterase activity of the mouse epididymis after 24, 48, and 72 hr castration is reported. Differential sensitivity to androgen deprivation among the various epithelial cell types is described, allowing of positive identification of the cell types previously observed to survive long-term castration. The possibility of an androgen binding protein, as described in the rat and rabbit, is suggested on morphological grounds. The epididymal body appears to contain a class of highly androgen sensitive cells that degenerate rapidly following castration and a second class that survive from which regeneration occurs on testosterone replacement.

M3 - Journal article

C2 - 6847305

VL - 10

SP - 51

EP - 55

JO - Systems Biology in Reproductive Medicine

JF - Systems Biology in Reproductive Medicine

SN - 1939-6368

IS - 1

ER -