High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study. / Nielsen, Marc Østergaard; Petersen, Nanna Aagaard; Coello, Klara; Stanislaus, Sharleny; Melbye, Sigurd A.; Kjærstad, Hanne Lie; Sletved, Kimie Stefanie Ormstrup; Frikke-Schmidt, Ruth; McIntyre, Roger S.; Vinberg, Maj; Kessing, Lars Vedel.

I: European psychiatry : the journal of the Association of European Psychiatrists, Bind 63, Nr. 1, 2020, s. e103.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, MØ, Petersen, NA, Coello, K, Stanislaus, S, Melbye, SA, Kjærstad, HL, Sletved, KSO, Frikke-Schmidt, R, McIntyre, RS, Vinberg, M & Kessing, LV 2020, 'High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study', European psychiatry : the journal of the Association of European Psychiatrists, bind 63, nr. 1, s. e103. https://doi.org/10.1192/j.eurpsy.2020.105

APA

Nielsen, M. Ø., Petersen, N. A., Coello, K., Stanislaus, S., Melbye, S. A., Kjærstad, H. L., Sletved, K. S. O., Frikke-Schmidt, R., McIntyre, R. S., Vinberg, M., & Kessing, L. V. (2020). High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study. European psychiatry : the journal of the Association of European Psychiatrists, 63(1), e103. https://doi.org/10.1192/j.eurpsy.2020.105

Vancouver

Nielsen MØ, Petersen NA, Coello K, Stanislaus S, Melbye SA, Kjærstad HL o.a. High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study. European psychiatry : the journal of the Association of European Psychiatrists. 2020;63(1):e103. https://doi.org/10.1192/j.eurpsy.2020.105

Author

Nielsen, Marc Østergaard ; Petersen, Nanna Aagaard ; Coello, Klara ; Stanislaus, Sharleny ; Melbye, Sigurd A. ; Kjærstad, Hanne Lie ; Sletved, Kimie Stefanie Ormstrup ; Frikke-Schmidt, Ruth ; McIntyre, Roger S. ; Vinberg, Maj ; Kessing, Lars Vedel. / High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study. I: European psychiatry : the journal of the Association of European Psychiatrists. 2020 ; Bind 63, Nr. 1. s. e103.

Bibtex

@article{ee594ce098174badac1701a31e846303,
title = "High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study",
abstract = "BACKGROUND: Changes in inflammatory and metabolic markers are implicated in the pathogenesis in both the development and progression of bipolar disorder (BD). Notwithstanding, these markers have not been investigated in newly diagnosed BD. METHODS: We compared high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in 372 patients with newly diagnosed BD, 106 unaffected first-degree relatives (URs), and 201 healthy control persons (HCs). Within the patient group, we also investigated possible associations between hs-CRP and Hcy, respectively, with illness-related characteristics and psychotropic medication. RESULTS: No statistically significant differences in Hcy and hs-CRP levels were found when comparing BD and URs with HCs. Similarly, there were no differences when comparing only patients in remission or patients with affective symptoms, respectively, with HCs. Hcy levels were found to be 11.9% (95% CI: 1.030-1.219) higher in patients with BD when compared with their URs (p = 0.008), when adjusting for folate and cobalamin status, age, sex, and self-reported activity levels. Hcy levels were significantly associated with folate, cobalamin, gender, and age in all models (p < 0.05). CONCLUSION: Our results do not support hs-CRP or Hcy as markers in newly diagnosed BD.",
keywords = "Bipolar disorder, C-reactive protein, homocysteine, unaffected relatives",
author = "Nielsen, {Marc {\O}stergaard} and Petersen, {Nanna Aagaard} and Klara Coello and Sharleny Stanislaus and Melbye, {Sigurd A.} and Kj{\ae}rstad, {Hanne Lie} and Sletved, {Kimie Stefanie Ormstrup} and Ruth Frikke-Schmidt and McIntyre, {Roger S.} and Maj Vinberg and Kessing, {Lars Vedel}",
year = "2020",
doi = "10.1192/j.eurpsy.2020.105",
language = "English",
volume = "63",
pages = "e103",
journal = "European Psychiatry",
issn = "0924-9338",
publisher = "Elsevier Masson",
number = "1",

}

RIS

TY - JOUR

T1 - High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons-Results from a clinical study

AU - Nielsen, Marc Østergaard

AU - Petersen, Nanna Aagaard

AU - Coello, Klara

AU - Stanislaus, Sharleny

AU - Melbye, Sigurd A.

AU - Kjærstad, Hanne Lie

AU - Sletved, Kimie Stefanie Ormstrup

AU - Frikke-Schmidt, Ruth

AU - McIntyre, Roger S.

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Changes in inflammatory and metabolic markers are implicated in the pathogenesis in both the development and progression of bipolar disorder (BD). Notwithstanding, these markers have not been investigated in newly diagnosed BD. METHODS: We compared high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in 372 patients with newly diagnosed BD, 106 unaffected first-degree relatives (URs), and 201 healthy control persons (HCs). Within the patient group, we also investigated possible associations between hs-CRP and Hcy, respectively, with illness-related characteristics and psychotropic medication. RESULTS: No statistically significant differences in Hcy and hs-CRP levels were found when comparing BD and URs with HCs. Similarly, there were no differences when comparing only patients in remission or patients with affective symptoms, respectively, with HCs. Hcy levels were found to be 11.9% (95% CI: 1.030-1.219) higher in patients with BD when compared with their URs (p = 0.008), when adjusting for folate and cobalamin status, age, sex, and self-reported activity levels. Hcy levels were significantly associated with folate, cobalamin, gender, and age in all models (p < 0.05). CONCLUSION: Our results do not support hs-CRP or Hcy as markers in newly diagnosed BD.

AB - BACKGROUND: Changes in inflammatory and metabolic markers are implicated in the pathogenesis in both the development and progression of bipolar disorder (BD). Notwithstanding, these markers have not been investigated in newly diagnosed BD. METHODS: We compared high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in 372 patients with newly diagnosed BD, 106 unaffected first-degree relatives (URs), and 201 healthy control persons (HCs). Within the patient group, we also investigated possible associations between hs-CRP and Hcy, respectively, with illness-related characteristics and psychotropic medication. RESULTS: No statistically significant differences in Hcy and hs-CRP levels were found when comparing BD and URs with HCs. Similarly, there were no differences when comparing only patients in remission or patients with affective symptoms, respectively, with HCs. Hcy levels were found to be 11.9% (95% CI: 1.030-1.219) higher in patients with BD when compared with their URs (p = 0.008), when adjusting for folate and cobalamin status, age, sex, and self-reported activity levels. Hcy levels were significantly associated with folate, cobalamin, gender, and age in all models (p < 0.05). CONCLUSION: Our results do not support hs-CRP or Hcy as markers in newly diagnosed BD.

KW - Bipolar disorder

KW - C-reactive protein

KW - homocysteine

KW - unaffected relatives

U2 - 10.1192/j.eurpsy.2020.105

DO - 10.1192/j.eurpsy.2020.105

M3 - Journal article

C2 - 33234170

AN - SCOPUS:85098531686

VL - 63

SP - e103

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

IS - 1

ER -

ID: 255211281