High long-term test–retest reliability for extrastriatal 11C-raclopride binding in healthy older adults
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High long-term test–retest reliability for extrastriatal 11C-raclopride binding in healthy older adults. / Karalija, Nina; Jonassson, Lars; Johansson, Jarkko; Papenberg, Goran; Salami, Alireza; Andersson, Micael; Riklund, Katrine; Nyberg, Lars; Boraxbekk, Carl Johan.
I: Journal of Cerebral Blood Flow and Metabolism, Bind 40, Nr. 9, 2020, s. 1859-1868.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - High long-term test–retest reliability for extrastriatal 11C-raclopride binding in healthy older adults
AU - Karalija, Nina
AU - Jonassson, Lars
AU - Johansson, Jarkko
AU - Papenberg, Goran
AU - Salami, Alireza
AU - Andersson, Micael
AU - Riklund, Katrine
AU - Nyberg, Lars
AU - Boraxbekk, Carl Johan
N1 - Publisher Copyright: © The Author(s) 2019.
PY - 2020
Y1 - 2020
N2 - In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test–retest reliability in a sample of younger adults. The present work demonstrates high seven-month test–retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64–78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85–0.96), absolute variability was low (mean: 4–8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.
AB - In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test–retest reliability in a sample of younger adults. The present work demonstrates high seven-month test–retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64–78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85–0.96), absolute variability was low (mean: 4–8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (ρ = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: ρ = 0.92; p < 0.001; excluding striatum: ρ = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.
KW - C-raclopride
KW - binding potential
KW - extrastriatal
KW - positron emission tomography
KW - reliability
U2 - 10.1177/0271678X19874770
DO - 10.1177/0271678X19874770
M3 - Journal article
C2 - 31506011
AN - SCOPUS:85073987923
VL - 40
SP - 1859
EP - 1868
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 9
ER -
ID: 332184895