High interleukin-6 mRNA expression is a predictor of relapse in colon cancer

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Standard

High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. / Olsen, Jesper; Kirkeby, Lene T; Olsen, Jørgen; Eiholm, Susanne; Jess, Per; Gögenur, Ismail; Troelsen, Jesper T.

I: Anticancer Research, Bind 35, Nr. 4, 04.2015, s. 2235-40.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Olsen, J, Kirkeby, LT, Olsen, J, Eiholm, S, Jess, P, Gögenur, I & Troelsen, JT 2015, 'High interleukin-6 mRNA expression is a predictor of relapse in colon cancer', Anticancer Research, bind 35, nr. 4, s. 2235-40. <http://ar.iiarjournals.org/content/35/4/2235.abstract>

APA

Olsen, J., Kirkeby, L. T., Olsen, J., Eiholm, S., Jess, P., Gögenur, I., & Troelsen, J. T. (2015). High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. Anticancer Research, 35(4), 2235-40. http://ar.iiarjournals.org/content/35/4/2235.abstract

Vancouver

Olsen J, Kirkeby LT, Olsen J, Eiholm S, Jess P, Gögenur I o.a. High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. Anticancer Research. 2015 apr.;35(4):2235-40.

Author

Olsen, Jesper ; Kirkeby, Lene T ; Olsen, Jørgen ; Eiholm, Susanne ; Jess, Per ; Gögenur, Ismail ; Troelsen, Jesper T. / High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. I: Anticancer Research. 2015 ; Bind 35, Nr. 4. s. 2235-40.

Bibtex

@article{3e24cce14f844445913dd214654bdd6e,

title = "High interleukin-6 mRNA expression is a predictor of relapse in colon cancer",

abstract = "AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression.MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model.RESULTS: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05).CONCLUSION: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.",

author = "Jesper Olsen and Kirkeby, {Lene T} and J{\o}rgen Olsen and Susanne Eiholm and Per Jess and Ismail G{\"o}genur and Troelsen, {Jesper T}",

year = "2015",

month = apr,

language = "English",

volume = "35",

pages = "2235--40",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

RIS

TY - JOUR

T1 - High interleukin-6 mRNA expression is a predictor of relapse in colon cancer

AU - Olsen, Jesper

AU - Kirkeby, Lene T

AU - Olsen, Jørgen

AU - Eiholm, Susanne

AU - Jess, Per

AU - Gögenur, Ismail

AU - Troelsen, Jesper T

PY - 2015/4

Y1 - 2015/4

N2 - AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression.MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model.RESULTS: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05).CONCLUSION: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.

AB - AIM: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression.MATERIALS AND METHODS: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction. Survival analyses were carried-out using a Cox competing risk regression model.RESULTS: IL6 mRNA was significantly more highly expressed in tumor tissue compared to normal adjacent tissue (p<0.001). We found no significant association with regard to IL6 expression and histological differentiation or cancer stage. We found a significant association between high IL6 expression and risk of relapse (Hazard Ratio=2.23, 95% CI=1.10-4.53; p<0.05), also when adjusted for clinicopathological characteristics (Hazard Ratio=2.16, 95% CI=1.07-4.40; p<0.05).CONCLUSION: Interleukin-6 is up-regulated in colon cancer tissue at the transcriptional level and is significantly associated with increased risk of relapse.

M3 - Journal article

C2 - 25862884

VL - 35

SP - 2235

EP - 2240

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4

ER -

ID: 138764413