Hepatitis C prevalence in Denmark in 2016—An updated estimate using multiple national registers
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Hepatitis C prevalence in Denmark in 2016—An updated estimate using multiple national registers. / Nielsen, Stine; Hansen, Janne Fuglsang; Hay, Gordon; Cowan, Susan; Jepsen, Peter; Omland, Lars Haukali; Krarup, Henrik Bygum; Søholm, Jacob; Lazarus, Jeffrey V.; Weis, Nina; Øvrehus, Anne; Christensen, Peer Brehm.
I: PLoS ONE, Bind 15, Nr. 9 September 2020, e0238203, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Hepatitis C prevalence in Denmark in 2016—An updated estimate using multiple national registers
AU - Nielsen, Stine
AU - Hansen, Janne Fuglsang
AU - Hay, Gordon
AU - Cowan, Susan
AU - Jepsen, Peter
AU - Omland, Lars Haukali
AU - Krarup, Henrik Bygum
AU - Søholm, Jacob
AU - Lazarus, Jeffrey V.
AU - Weis, Nina
AU - Øvrehus, Anne
AU - Christensen, Peer Brehm
PY - 2020
Y1 - 2020
N2 - Background Chronic hepatitis C (CHC) can be eliminated as a public health threat by meeting the WHO targets: 90% of patients diagnosed and 80% treated by 2030. To achieve and monitor progress towards elimination, an updated estimate of the size of the CHC population is needed, but Denmark has no complete national CHC register. By combining existing registers in 2007, we estimated the population living with CHC to be 16,888 (0.38% of the adult population). Aim To estimate the population living with diagnosed and undiagnosed CHC in Denmark on 31 December 2016. Among additional aims were to estimate the proportion of patients attending specialised clinical care. Methods People with diagnosed CHC were identified from four national registers. The total diagnosed population was estimated by capture-recapture analysis. The undiagnosed population was estimated by comparing the register data with data from two cross-sectional surveys. Results The population living with diagnosed CHC in Denmark was 7,581 persons (95%CI: 7,416–12,661) of which 6,116 (81%) were identified in the four registers. The estimated undiagnosed fraction was 24%, so the total CHC infected population was 9,975 corresponding to 0.21% of the adult population (95%CI: 9,758–16,659; 0.21%-0.36%). Only 48% of diagnosed patients had received specialised clinical care. Conclusion CHC prevalence in Denmark is declining and 76% of patients have been diagnosed. Linking diagnosed patients to care and increasing efforts to test people with former or current drug use will be necessary to achieve CHC elimination.
AB - Background Chronic hepatitis C (CHC) can be eliminated as a public health threat by meeting the WHO targets: 90% of patients diagnosed and 80% treated by 2030. To achieve and monitor progress towards elimination, an updated estimate of the size of the CHC population is needed, but Denmark has no complete national CHC register. By combining existing registers in 2007, we estimated the population living with CHC to be 16,888 (0.38% of the adult population). Aim To estimate the population living with diagnosed and undiagnosed CHC in Denmark on 31 December 2016. Among additional aims were to estimate the proportion of patients attending specialised clinical care. Methods People with diagnosed CHC were identified from four national registers. The total diagnosed population was estimated by capture-recapture analysis. The undiagnosed population was estimated by comparing the register data with data from two cross-sectional surveys. Results The population living with diagnosed CHC in Denmark was 7,581 persons (95%CI: 7,416–12,661) of which 6,116 (81%) were identified in the four registers. The estimated undiagnosed fraction was 24%, so the total CHC infected population was 9,975 corresponding to 0.21% of the adult population (95%CI: 9,758–16,659; 0.21%-0.36%). Only 48% of diagnosed patients had received specialised clinical care. Conclusion CHC prevalence in Denmark is declining and 76% of patients have been diagnosed. Linking diagnosed patients to care and increasing efforts to test people with former or current drug use will be necessary to achieve CHC elimination.
U2 - 10.1371/journal.pone.0238203
DO - 10.1371/journal.pone.0238203
M3 - Journal article
C2 - 32881877
AN - SCOPUS:85090319476
VL - 15
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9 September 2020
M1 - e0238203
ER -
ID: 250969765