TY - JOUR

T1 - Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy

AU - Wulff, Nille B.

AU - Dalton, Susanne O.

AU - Wessel, Irene

AU - Arenaz Búa, Beatriz

AU - Löfhede, Helena

AU - Hammerlid, Eva

AU - Kjaer, Trille K.

AU - Godballe, Christian

AU - Kjærgaard, Thomas

AU - Homøe, Preben

N1 - Funding Information: This study was funded by the Region Zealand Fund for Health and Medical Sciences, the University of Copenhagen Fund for Cancer Research, the Medical Component of the Faculty of Health and Medical Sciences Fund for Scientific Staff, the Danish Cancer Research Fund, and the Danish‐Swedish Cooperation Fund. Publisher Copyright: © 2021 The American Laryngological, Rhinological and Otological Society, Inc.

PY - 2022

Y1 - 2022

N2 - Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 2021.

AB - Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 2021.

KW - depression

KW - dysphagia

KW - health-related quality of life

KW - Total laryngectomy

KW - voice problems

U2 - 10.1002/lary.29857

DO - 10.1002/lary.29857

M3 - Journal article

C2 - 34490903

AN - SCOPUS:85114472353

VL - 132

SP - 980

EP - 988

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 5

ER -