TY - JOUR

T1 - Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain

AU - Rieckmann, Nina

AU - Neumann, Konrad

AU - Feger, Sarah

AU - Ibes, Paolo

AU - Napp, Adriane

AU - Preuß, Daniel

AU - Dreger, Henryk

AU - Feuchtner, Gudrun

AU - Plank, Fabian

AU - Suchánek, Vojtěch

AU - Veselka, Josef

AU - Engstrøm, Thomas

AU - Kofoed, Klaus F

AU - Schröder, Stephen

AU - Zelesny, Thomas

AU - Gutberlet, Matthias

AU - Woinke, Michael

AU - Maurovich-Horvat, Pál

AU - Merkely, Béla

AU - Donnelly, Patrick

AU - Ball, Peter

AU - Dodd, Jonathan D

AU - Hensey, Mark

AU - Loi, Bruno

AU - Saba, Luca

AU - Francone, Marco

AU - Mancone, Massimo

AU - Berzina, Marina

AU - Erglis, Andrejs

AU - Vaitiekiene, Audrone

AU - Zajanckauskiene, Laura

AU - Harań, Tomasz

AU - Suckiel, Malgorzata Ilnicka

AU - Faria, Rita

AU - Gama-Ribeiro, Vasco

AU - Benedek, Imre

AU - Rodean, Ioana

AU - Adjić, Filip

AU - Čemerlić Adjić, Nada

AU - Rodriguez-Palomares, José

AU - Garcia Del Blanco, Bruno

AU - Brooksbank, Katriona

AU - Collison, Damien

AU - Davis, Gershan

AU - Thwaite, Erica

AU - Knuuti, Juhani

AU - Saraste, Antti

AU - Kępka, Cezary

AU - Kruk, Mariusz

AU - Benedek, Theodora

AU - Ratiu, Mihaela

AU - Neskovic, Aleksandar N

AU - Vidakovic, Radosav

AU - Diez, Ignacio

AU - Lecumberri, Iñigo

AU - Fisher, Michael

AU - Ruzsics, Balazs

AU - Hollingworth, William

AU - Gutiérrez-Ibarluzea, Iñaki

AU - Dewey, Marc

AU - Müller-Nordhorn, Jacqueline

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.

AB - BACKGROUND: Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.

KW - Aged

KW - Angina Pectoris/classification

KW - Coronary Artery Disease/diagnosis

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Quality of Life

KW - Sex Distribution

KW - Surveys and Questionnaires

U2 - 10.1186/s12955-020-01312-4

DO - 10.1186/s12955-020-01312-4

M3 - Journal article

C2 - 32410687

VL - 18

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

SN - 1477-7525

M1 - 140

ER -