Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome: a systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome : a systematic review. / Árnadóttir, Ásthildur; Falk Klein, Christine; Iversen, Kasper.
I: Biomarkers, Bind 22, Nr. 8, 2017, s. 701-708.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome
T2 - a systematic review
AU - Árnadóttir, Ásthildur
AU - Falk Klein, Christine
AU - Iversen, Kasper
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Cardiac-specific troponin T (cTnT) and troponin I (cTnI) are considered diagnostically equal in patients with acute coronary syndrome (ACS). The aim of this systematic review was to compare the prevalence and prognostic strength of elevations of cTnT and cTnI in patients with other conditions than ACS.METHODS: A systemic review was conducted in concordance with the PRISMA guidelines. The studies were identified by searching PubMed, EMBASE and Cochrane Central Register, from May to August 2016. Studies measuring both cTnT and cTnI in populations without ACS were eligible.RESULTS: Twenty-nine studies were included (n = 25,859). Seventeen studies reported on prognostic information with follow-up time ranging for 30 d-5 years. Elevation above the 99th percentile (reference value for a healthy population) in non-ACS population was reported to be 0-39% for cTnI and 40-100% for cTnT. Elevation of cTnT tends to be a superior predictor for all-cause mortality and elevation of cTnI tends to be a superior predictor for cardiovascular related mortality.DISCUSSION: In the absence of ACS, elevation of cTnT is more frequent than elevation of cTnI.CONCLUSION: Both cTnT and cTnI elevations have important prognostic information regarding morbidity, cardiac mortality and all-cause mortality.
AB - BACKGROUND: Cardiac-specific troponin T (cTnT) and troponin I (cTnI) are considered diagnostically equal in patients with acute coronary syndrome (ACS). The aim of this systematic review was to compare the prevalence and prognostic strength of elevations of cTnT and cTnI in patients with other conditions than ACS.METHODS: A systemic review was conducted in concordance with the PRISMA guidelines. The studies were identified by searching PubMed, EMBASE and Cochrane Central Register, from May to August 2016. Studies measuring both cTnT and cTnI in populations without ACS were eligible.RESULTS: Twenty-nine studies were included (n = 25,859). Seventeen studies reported on prognostic information with follow-up time ranging for 30 d-5 years. Elevation above the 99th percentile (reference value for a healthy population) in non-ACS population was reported to be 0-39% for cTnI and 40-100% for cTnT. Elevation of cTnT tends to be a superior predictor for all-cause mortality and elevation of cTnI tends to be a superior predictor for cardiovascular related mortality.DISCUSSION: In the absence of ACS, elevation of cTnT is more frequent than elevation of cTnI.CONCLUSION: Both cTnT and cTnI elevations have important prognostic information regarding morbidity, cardiac mortality and all-cause mortality.
U2 - 10.1080/1354750X.2017.1335779
DO - 10.1080/1354750X.2017.1335779
M3 - Review
C2 - 28545334
VL - 22
SP - 701
EP - 708
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 8
ER -
ID: 195162989