Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

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Standard

Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. / Coello, Klara; Munkholm, Klaus; Nielsen, Flemming; Vinberg, Maj; Kessing, Lars Vedel.

I: Psychoneuroendocrinology, Bind 99, 2019, s. 183-190.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Coello, K, Munkholm, K, Nielsen, F, Vinberg, M & Kessing, LV 2019, 'Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives', Psychoneuroendocrinology, bind 99, s. 183-190. https://doi.org/10.1016/j.psyneuen.2018.09.020

APA

Coello, K., Munkholm, K., Nielsen, F., Vinberg, M., & Kessing, L. V. (2019). Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. Psychoneuroendocrinology, 99, 183-190. https://doi.org/10.1016/j.psyneuen.2018.09.020

Vancouver

Coello K, Munkholm K, Nielsen F, Vinberg M, Kessing LV. Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. Psychoneuroendocrinology. 2019;99:183-190. https://doi.org/10.1016/j.psyneuen.2018.09.020

Author

Coello, Klara ; Munkholm, Klaus ; Nielsen, Flemming ; Vinberg, Maj ; Kessing, Lars Vedel. / Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. I: Psychoneuroendocrinology. 2019 ; Bind 99. s. 183-190.

Bibtex

@article{0916bab1dee542d9ad59241b306f89ae,

title = "Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives",

abstract = "OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1% (95%CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.",

keywords = "Adult, Biomarkers, Bipolar Disorder/metabolism, Case-Control Studies, Cross-Sectional Studies, Family/psychology, Female, Hair/chemistry, Humans, Hydrocortisone/analysis, Male, Retrospective Studies, Stress, Physiological/physiology, Young Adult",

author = "Klara Coello and Klaus Munkholm and Flemming Nielsen and Maj Vinberg and Kessing, {Lars Vedel}",

year = "2019",

doi = "10.1016/j.psyneuen.2018.09.020",

language = "English",

volume = "99",

pages = "183--190",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

AU - Coello, Klara

AU - Munkholm, Klaus

AU - Nielsen, Flemming

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1% (95%CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.

AB - OBJECTIVE: Hair cortisol is a promising new biomarker of retrospective systemic cortisol concentration. In this study, we compared hair cortisol concentrations in patients with newly diagnosed bipolar disorder (BD), their unaffected first-degree relatives and healthy individuals and identified potential predictors of hair cortisol concentrations in patients with BD.METHOD: In a cross-sectional design, we compared hair cortisol concentrations in 181 patients with newly diagnosed/first episode BD, 42 of their unaffected first-degree relatives and 101 healthy age- and sex-matched individuals with no personal or first-degree family history of affective disorder. In patients with BD, we further investigated whether medication- and illness related variables, as well as measures of stressful life events in the preceding 12 months and childhood trauma, were associated with hair cortisol concentrations.RESULTS: Hair cortisol concentrations were 35.1% (95%CI: 13.0-61.5) higher in patients with BD (P = 0.001) compared with healthy individuals in models adjusted for age and sex. Hair cortisol concentrations in unaffected first-degree relatives did not differ from healthy individuals (P = 0.8). In patients, neither medication, illness duration nor stress related variables were associated with hair cortisol concentrations.CONCLUSION: We found elevated hair cortisol concentrations in patients newly diagnosed with BD indicating the presence of physiological stress in early stages of BD.

KW - Adult

KW - Biomarkers

KW - Bipolar Disorder/metabolism

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Family/psychology

KW - Female

KW - Hair/chemistry

KW - Humans

KW - Hydrocortisone/analysis

KW - Male

KW - Retrospective Studies

KW - Stress, Physiological/physiology

KW - Young Adult

U2 - 10.1016/j.psyneuen.2018.09.020

DO - 10.1016/j.psyneuen.2018.09.020

M3 - Journal article

C2 - 30248494

VL - 99

SP - 183

EP - 190

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 224599892