Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
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Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. / Dashti, Hassan S; Follis, Jack L; Smith, Caren E; Tanaka, Toshiko; Cade, Brian E; Gottlieb, Daniel J; Hruby, Adela; Jacques, Paul F; Lamon-Fava, Stefania; Richardson, Kris; Saxena, Richa; Scheer, Frank A J L; Kovanen, Leena; Bartz, Traci M; Perälä, Mia-Maria; Jonsson, Anna Elisabet; Frazier-Wood, Alexis C; Kalafati, Ioanna-Panagiota; Mikkilä, Vera; Partonen, Timo; Lemaitre, Rozenn N; Lahti, Jari; Hernandez, Dena G; Toft, Ulla; Johnson, W Craig; Kanoni, Stavroula; Raitakari, Olli T; Perola, Markus; Psaty, Bruce M; Ferrucci, Luigi; Grarup, Niels; Highland, Heather M; Rallidis, Loukianos; Kähönen, Mika; Havulinna, Aki S; Siscovick, David S; Räikkönen, Katri; Jørgensen, Torben; Rotter, Jerome I; Deloukas, Panos; Viikari, Jorma S A; Mozaffarian, Dariush; Linneberg, Allan; Seppälä, Ilkka; Hansen, Torben; Salomaa, Veikko; Gharib, Sina A; Eriksson, Johan G; Bandinelli, Stefania; Pedersen, Oluf; Rich, Stephen S; Dedoussis, George; Lehtimäki, Terho; Ordovás, José M.
I: The American Journal of Clinical Nutrition, Bind 101, Nr. 1, 01.2015, s. 135-43.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
AU - Dashti, Hassan S
AU - Follis, Jack L
AU - Smith, Caren E
AU - Tanaka, Toshiko
AU - Cade, Brian E
AU - Gottlieb, Daniel J
AU - Hruby, Adela
AU - Jacques, Paul F
AU - Lamon-Fava, Stefania
AU - Richardson, Kris
AU - Saxena, Richa
AU - Scheer, Frank A J L
AU - Kovanen, Leena
AU - Bartz, Traci M
AU - Perälä, Mia-Maria
AU - Jonsson, Anna Elisabet
AU - Frazier-Wood, Alexis C
AU - Kalafati, Ioanna-Panagiota
AU - Mikkilä, Vera
AU - Partonen, Timo
AU - Lemaitre, Rozenn N
AU - Lahti, Jari
AU - Hernandez, Dena G
AU - Toft, Ulla
AU - Johnson, W Craig
AU - Kanoni, Stavroula
AU - Raitakari, Olli T
AU - Perola, Markus
AU - Psaty, Bruce M
AU - Ferrucci, Luigi
AU - Grarup, Niels
AU - Highland, Heather M
AU - Rallidis, Loukianos
AU - Kähönen, Mika
AU - Havulinna, Aki S
AU - Siscovick, David S
AU - Räikkönen, Katri
AU - Jørgensen, Torben
AU - Rotter, Jerome I
AU - Deloukas, Panos
AU - Viikari, Jorma S A
AU - Mozaffarian, Dariush
AU - Linneberg, Allan
AU - Seppälä, Ilkka
AU - Hansen, Torben
AU - Salomaa, Veikko
AU - Gharib, Sina A
AU - Eriksson, Johan G
AU - Bandinelli, Stefania
AU - Pedersen, Oluf
AU - Rich, Stephen S
AU - Dedoussis, George
AU - Lehtimäki, Terho
AU - Ordovás, José M
N1 - © 2015 American Society for Nutrition.
PY - 2015/1
Y1 - 2015/1
N2 - BACKGROUND: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake.OBJECTIVES: We examined associations between habitual sleep duration, body mass index (BMI), and macronutrient intake and assessed whether CLOCK variants modify these associations.DESIGN: We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.RESULTS: We observed a significant association between sleep duration and lower BMI (β ± SE = 0.16 ± 0.04, P < 0.0001) in the overall sample; however, associations between sleep duration and relative macronutrient intake were evident in age- and sex-stratified analyses only. We observed a significant association between sleep duration and lower saturated fatty acid intake in younger (aged 20-64 y) adults (men: 0.11 ± 0.06%, P = 0.03; women: 0.10 ± 0.05%, P = 0.04) and with lower carbohydrate (-0.31 ± 0.12%, P < 0.01), higher total fat (0.18 ± 0.09%, P = 0.05), and higher PUFA (0.05 ± 0.02%, P = 0.02) intakes in older (aged 65-80 y) women. In addition, the following 2 nominally significant interactions were observed: between sleep duration and rs12649507 on PUFA intake and between sleep duration and rs6858749 on protein intake.CONCLUSIONS: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.
AB - BACKGROUND: Short sleep duration has been associated with greater risks of obesity, hypertension, diabetes, and cardiovascular disease. Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake.OBJECTIVES: We examined associations between habitual sleep duration, body mass index (BMI), and macronutrient intake and assessed whether CLOCK variants modify these associations.DESIGN: We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations of sleep duration and BMI and macronutrient intake as percentages of total energy as well as interactions with CLOCK variants from 9 cohort studies including up to 14,906 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.RESULTS: We observed a significant association between sleep duration and lower BMI (β ± SE = 0.16 ± 0.04, P < 0.0001) in the overall sample; however, associations between sleep duration and relative macronutrient intake were evident in age- and sex-stratified analyses only. We observed a significant association between sleep duration and lower saturated fatty acid intake in younger (aged 20-64 y) adults (men: 0.11 ± 0.06%, P = 0.03; women: 0.10 ± 0.05%, P = 0.04) and with lower carbohydrate (-0.31 ± 0.12%, P < 0.01), higher total fat (0.18 ± 0.09%, P = 0.05), and higher PUFA (0.05 ± 0.02%, P = 0.02) intakes in older (aged 65-80 y) women. In addition, the following 2 nominally significant interactions were observed: between sleep duration and rs12649507 on PUFA intake and between sleep duration and rs6858749 on protein intake.CONCLUSIONS: Our results indicate that longer habitual sleep duration is associated with lower BMI and age- and sex-specific favorable dietary behaviors. Differences in the relative intake of specific macronutrients associated with short sleep duration could, at least in part, explain previously reported associations between short sleep duration and chronic metabolic abnormalities. In addition, the influence of obesity-associated CLOCK variants on the association between sleep duration and macronutrient intake suggests that longer habitual sleep duration could ameliorate the genetic predisposition to obesity via a favorable dietary profile.
KW - Adult
KW - Body Mass Index
KW - CLOCK Proteins
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Diet
KW - Dietary Proteins
KW - Energy Intake
KW - European Continental Ancestry Group
KW - Fatty Acids, Unsaturated
KW - Female
KW - Gene-Environment Interaction
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Middle Aged
KW - Obesity
KW - Polymorphism, Single Nucleotide
KW - Sleep
KW - Young Adult
U2 - 10.3945/ajcn.114.095026
DO - 10.3945/ajcn.114.095026
M3 - Journal article
C2 - 25527757
VL - 101
SP - 135
EP - 143
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -
ID: 135450032