Gynaecomastia in 786 adult men: clinical and biochemical findings
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Gynaecomastia in 786 adult men : clinical and biochemical findings. / Mieritz, Mikkel G; Christiansen, Peter; Jensen, Martin Blomberg; Joensen, Ulla N; Nordkap, Loa; Olesen, Inge A; Bang, A Kirstine; Juul, Anders; Jørgensen, Niels.
I: European Journal of Endocrinology, Bind 176, Nr. 5, 2017, s. 555-566.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Gynaecomastia in 786 adult men
T2 - clinical and biochemical findings
AU - Mieritz, Mikkel G
AU - Christiansen, Peter
AU - Jensen, Martin Blomberg
AU - Joensen, Ulla N
AU - Nordkap, Loa
AU - Olesen, Inge A
AU - Bang, A Kirstine
AU - Juul, Anders
AU - Jørgensen, Niels
N1 - © 2017 European Society of Endocrinology.
PY - 2017
Y1 - 2017
N2 - OBJECTIVE: Gynaecomastia is a benign proliferation of glandular tissue of the breast; however, it is an important clinical observation because it can be the first symptom of an underlying disease. Some controversy exists concerning the clinical importance of an in-depth investigation of men who develop gynaecomastia. We hypothesise that a thorough work-up is required in adult men with gynaecomastia.DESIGN: All adult men (n = 818) referred to a secondary level andrological department at Rigshospitalet in Copenhagen, Denmark during a four-year period (2008-2011) under the diagnosis of gynaecomastia (ICD-10: N62) were included.METHODS: Thirty-two men who did not have gynaecomastia when examined were excluded; leaving 786 men for final analyses. They underwent an andrological examination, ultrasound of the testicles and analysis of endogenous serum hormones levels.RESULTS: In 43% of men with adult onset of gynaecomastia (≥18 years) an underlying, and often treatable, cause could be detected. In men younger at onset an underlying cause for gynaecomastia could be detected in merely 7.7%. The study is limited by the fact that we did not have access to investigate men who were referred directly by their GP to private clinics for plastic surgery or who sought cosmetic correction without consulting their GP first.CONCLUSIONS: Our study demonstrates the importance of a thorough examination and provides a comprehensible examination strategy to disclose the underlying pathology leading to the development of gynaecomastia in adulthood.
AB - OBJECTIVE: Gynaecomastia is a benign proliferation of glandular tissue of the breast; however, it is an important clinical observation because it can be the first symptom of an underlying disease. Some controversy exists concerning the clinical importance of an in-depth investigation of men who develop gynaecomastia. We hypothesise that a thorough work-up is required in adult men with gynaecomastia.DESIGN: All adult men (n = 818) referred to a secondary level andrological department at Rigshospitalet in Copenhagen, Denmark during a four-year period (2008-2011) under the diagnosis of gynaecomastia (ICD-10: N62) were included.METHODS: Thirty-two men who did not have gynaecomastia when examined were excluded; leaving 786 men for final analyses. They underwent an andrological examination, ultrasound of the testicles and analysis of endogenous serum hormones levels.RESULTS: In 43% of men with adult onset of gynaecomastia (≥18 years) an underlying, and often treatable, cause could be detected. In men younger at onset an underlying cause for gynaecomastia could be detected in merely 7.7%. The study is limited by the fact that we did not have access to investigate men who were referred directly by their GP to private clinics for plastic surgery or who sought cosmetic correction without consulting their GP first.CONCLUSIONS: Our study demonstrates the importance of a thorough examination and provides a comprehensible examination strategy to disclose the underlying pathology leading to the development of gynaecomastia in adulthood.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Biomarkers/blood
KW - Denmark/epidemiology
KW - Gynecomastia/blood
KW - Humans
KW - Male
KW - Middle Aged
KW - Testosterone/blood
KW - Young Adult
U2 - 10.1530/EJE-16-0643
DO - 10.1530/EJE-16-0643
M3 - Journal article
C2 - 28179453
VL - 176
SP - 555
EP - 566
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 5
ER -
ID: 194913146