Standard
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. / Pharoah, Paul D P; Tsai, Ya-Yu; Ramus, Susan J; Phelan, Catherine M; Goode, Ellen L; Lawrenson, Kate; Buckley, Melissa; Fridley, Brooke L; Tyrer, Jonathan P; Shen, Howard; Weber, Rachel; Karevan, Rod; Larson, Melissa C; Song, Honglin; Tessier, Daniel C; Bacot, François; Vincent, Daniel; Cunningham, Julie M; Dennis, Joe; Dicks, Ed; Aben, Katja K; Anton-Culver, Hoda; Antonenkova, Natalia; Armasu, Sebastian M; Baglietto, Laura; Bandera, Elisa V; Beckmann, Matthias W; Birrer, Michael J; Bloom, Greg; Bogdanova, Natalia; Brenton, James D; Brinton, Louise A; Brooks-Wilson, Angela; Brown, Robert James (Jim); Butzow, Ralf; Campbell, Ian; Carney, Michael E; Carvalho, Renato S; Chang-Claude, Jenny; Chen, Y Anne; Chen, Zhihua; Chow, Wong-Ho; Cicek, Mine S; Coetzee, Gerhard; Cook, Linda S; Cramer, Daniel W; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Despierre, Evelyn; Doherty, Jennifer A; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana; Edwards, Robert; Ekici, Arif B; Fasching, Peter A; Fenstermacher, David; Flanagan, James; Gao, Yu-Tang; Garcia-Closas, Montserrat; Gentry-Maharaj, Aleksandra; Giles, Graham; Gjyshi, Anxhela; Gore, Martin; Gronwald, Jacek; Guo, Qi; Halle, Mari K; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hillemanns, Peter; Hoatlin, Maureen; Høgdall, Estrid; Høgdall, Claus K; Hosono, Satoyo; Jakubowska, Anna; Jensen, Allan; Kalli, Kimberly R; Karlan, Beth Y; Kelemen, Linda E; Kiemeney, Lambertus A; Kjaer, Susanne Krüger; Konecny, Gottfried E; Krakstad, Camilla; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D; Lee, Nathan; Lee, Janet; Leminen, Arto; Lim, Boon Kiong; Lissowska, Jolanta; Lubi?ski, Jan; Lundvall, Lene; Lurie, Galina; Massuger, Leon F A G; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R; Menon, Usha; Modugno, Francesmary; Moysich, Kirsten B; Nakanishi, Toru; Narod, Steven A; Ness, Roberta B; Nevanlinna, Heli; Nickels, Stefan; Noushmehr, Houtan; Odunsi, Kunle; Olson, Sara; Orlow, Irene; Paul, James; Pejovic, Tanja; Pelttari, Liisa M; Permuth-Wey, Jenny; Pike, Malcolm C; Poole, Elizabeth M; Qu, Xiaotao; Risch, Harvey A; Rodriguez-Rodriguez, Lorna; Rossing, Mary Anne; Rudolph, Anja; Runnebaum, Ingo; Rzepecka, Iwona K; Salvesen, Helga B; Schwaab, Ira; Severi, Gianluca; Shen, Hui; Shridhar, Vijayalakshmi; Shu, Xiao-Ou; Sieh, Weiva; Southey, Melissa C; Spellman, Paul; Tajima, Kazuo; Teo, Soo-Hwang; Terry, Kathryn L; Thompson, Pamela J; Timorek, Agnieszka; Tworoger, Shelley S; van Altena, Anne M; van den Berg, David; Vergote, Ignace; Vierkant, Robert A; Vitonis, Allison F; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S; Wik, Elisabeth; Winterhoff, Boris; Woo, Yin Ling; Wu, Anna H; Yang, Hannah P; Zheng, Wei; Ziogas, Argyrios; Zulkifli, Famida; Goodman, Marc T; Hall, Per; Easton, Douglas F; Pearce, Celeste L; Berchuck, Andrew; Chenevix-Trench, Georgia; Iversen, Edwin; Monteiro, Alvaro N A; Gayther, Simon A; Schildkraut, Joellen M; Sellers, Thomas A; Study, Australian Cancer.
I:
Nature Genetics, Bind 45, Nr. 4, 04.2013, s. 362-70, 370e1-2.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Pharoah, PDP, Tsai, Y-Y, Ramus, SJ, Phelan, CM, Goode, EL, Lawrenson, K, Buckley, M, Fridley, BL, Tyrer, JP, Shen, H, Weber, R, Karevan, R, Larson, MC, Song, H, Tessier, DC, Bacot, F, Vincent, D, Cunningham, JM, Dennis, J, Dicks, E, Aben, KK, Anton-Culver, H, Antonenkova, N, Armasu, SM, Baglietto, L, Bandera, EV, Beckmann, MW, Birrer, MJ, Bloom, G, Bogdanova, N, Brenton, JD, Brinton, LA, Brooks-Wilson, A, Brown, RJJ, Butzow, R, Campbell, I, Carney, ME, Carvalho, RS, Chang-Claude, J, Chen, YA, Chen, Z, Chow, W-H, Cicek, MS, Coetzee, G, Cook, LS, Cramer, DW, Cybulski, C, Dansonka-Mieszkowska, A, Despierre, E, Doherty, JA, Dörk, T, du Bois, A, Dürst, M, Eccles, D, Edwards, R, Ekici, AB, Fasching, PA, Fenstermacher, D, Flanagan, J, Gao, Y-T, Garcia-Closas, M, Gentry-Maharaj, A, Giles, G, Gjyshi, A, Gore, M, Gronwald, J, Guo, Q, Halle, MK, Harter, P, Hein, A, Heitz, F, Hillemanns, P, Hoatlin, M
, Høgdall, E, Høgdall, CK, Hosono, S, Jakubowska, A, Jensen, A, Kalli, KR, Karlan, BY, Kelemen, LE, Kiemeney, LA
, Kjaer, SK, Konecny, GE, Krakstad, C, Kupryjanczyk, J, Lambrechts, D, Lambrechts, S, Le, ND, Lee, N, Lee, J, Leminen, A, Lim, BK, Lissowska, J, Lubi?ski, J, Lundvall, L, Lurie, G, Massuger, LFAG, Matsuo, K, McGuire, V, McLaughlin, JR, Menon, U, Modugno, F, Moysich, KB, Nakanishi, T, Narod, SA, Ness, RB, Nevanlinna, H, Nickels, S, Noushmehr, H, Odunsi, K, Olson, S, Orlow, I, Paul, J, Pejovic, T, Pelttari, LM, Permuth-Wey, J, Pike, MC, Poole, EM, Qu, X, Risch, HA, Rodriguez-Rodriguez, L, Rossing, MA, Rudolph, A, Runnebaum, I, Rzepecka, IK, Salvesen, HB, Schwaab, I, Severi, G, Shen, H, Shridhar, V, Shu, X-O, Sieh, W, Southey, MC, Spellman, P, Tajima, K, Teo, S-H, Terry, KL, Thompson, PJ, Timorek, A, Tworoger, SS, van Altena, AM, van den Berg, D, Vergote, I, Vierkant, RA, Vitonis, AF, Wang-Gohrke, S, Wentzensen, N, Whittemore, AS, Wik, E, Winterhoff, B, Woo, YL, Wu, AH, Yang, HP, Zheng, W, Ziogas, A, Zulkifli, F, Goodman, MT, Hall, P, Easton, DF, Pearce, CL, Berchuck, A, Chenevix-Trench, G, Iversen, E, Monteiro, ANA, Gayther, SA, Schildkraut, JM, Sellers, TA & Study, AC 2013, '
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer',
Nature Genetics, bind 45, nr. 4, s. 362-70, 370e1-2.
https://doi.org/10.1038/ng.2564APA
Pharoah, P. D. P., Tsai, Y-Y., Ramus, S. J., Phelan, C. M., Goode, E. L., Lawrenson, K., Buckley, M., Fridley, B. L., Tyrer, J. P., Shen, H., Weber, R., Karevan, R., Larson, M. C., Song, H., Tessier, D. C., Bacot, F., Vincent, D., Cunningham, J. M., Dennis, J., ... Study, A. C. (2013).
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Nature Genetics,
45(4), 362-70, 370e1-2.
https://doi.org/10.1038/ng.2564Vancouver
Pharoah PDP, Tsai Y-Y, Ramus SJ, Phelan CM, Goode EL, Lawrenson K o.a.
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Nature Genetics. 2013 apr.;45(4):362-70, 370e1-2.
https://doi.org/10.1038/ng.2564Author
Pharoah, Paul D P ; Tsai, Ya-Yu ; Ramus, Susan J ; Phelan, Catherine M ; Goode, Ellen L ; Lawrenson, Kate ; Buckley, Melissa ; Fridley, Brooke L ; Tyrer, Jonathan P ; Shen, Howard ; Weber, Rachel ; Karevan, Rod ; Larson, Melissa C ; Song, Honglin ; Tessier, Daniel C ; Bacot, François ; Vincent, Daniel ; Cunningham, Julie M ; Dennis, Joe ; Dicks, Ed ; Aben, Katja K ; Anton-Culver, Hoda ; Antonenkova, Natalia ; Armasu, Sebastian M ; Baglietto, Laura ; Bandera, Elisa V ; Beckmann, Matthias W ; Birrer, Michael J ; Bloom, Greg ; Bogdanova, Natalia ; Brenton, James D ; Brinton, Louise A ; Brooks-Wilson, Angela ; Brown, Robert James (Jim) ; Butzow, Ralf ; Campbell, Ian ; Carney, Michael E ; Carvalho, Renato S ; Chang-Claude, Jenny ; Chen, Y Anne ; Chen, Zhihua ; Chow, Wong-Ho ; Cicek, Mine S ; Coetzee, Gerhard ; Cook, Linda S ; Cramer, Daniel W ; Cybulski, Cezary ; Dansonka-Mieszkowska, Agnieszka ; Despierre, Evelyn ; Doherty, Jennifer A ; Dörk, Thilo ; du Bois, Andreas ; Dürst, Matthias ; Eccles, Diana ; Edwards, Robert ; Ekici, Arif B ; Fasching, Peter A ; Fenstermacher, David ; Flanagan, James ; Gao, Yu-Tang ; Garcia-Closas, Montserrat ; Gentry-Maharaj, Aleksandra ; Giles, Graham ; Gjyshi, Anxhela ; Gore, Martin ; Gronwald, Jacek ; Guo, Qi ; Halle, Mari K ; Harter, Philipp ; Hein, Alexander ; Heitz, Florian ; Hillemanns, Peter ; Hoatlin, Maureen ; Høgdall, Estrid ; Høgdall, Claus K ; Hosono, Satoyo ; Jakubowska, Anna ; Jensen, Allan ; Kalli, Kimberly R ; Karlan, Beth Y ; Kelemen, Linda E ; Kiemeney, Lambertus A ; Kjaer, Susanne Krüger ; Konecny, Gottfried E ; Krakstad, Camilla ; Kupryjanczyk, Jolanta ; Lambrechts, Diether ; Lambrechts, Sandrina ; Le, Nhu D ; Lee, Nathan ; Lee, Janet ; Leminen, Arto ; Lim, Boon Kiong ; Lissowska, Jolanta ; Lubi?ski, Jan ; Lundvall, Lene ; Lurie, Galina ; Massuger, Leon F A G ; Matsuo, Keitaro ; McGuire, Valerie ; McLaughlin, John R ; Menon, Usha ; Modugno, Francesmary ; Moysich, Kirsten B ; Nakanishi, Toru ; Narod, Steven A ; Ness, Roberta B ; Nevanlinna, Heli ; Nickels, Stefan ; Noushmehr, Houtan ; Odunsi, Kunle ; Olson, Sara ; Orlow, Irene ; Paul, James ; Pejovic, Tanja ; Pelttari, Liisa M ; Permuth-Wey, Jenny ; Pike, Malcolm C ; Poole, Elizabeth M ; Qu, Xiaotao ; Risch, Harvey A ; Rodriguez-Rodriguez, Lorna ; Rossing, Mary Anne ; Rudolph, Anja ; Runnebaum, Ingo ; Rzepecka, Iwona K ; Salvesen, Helga B ; Schwaab, Ira ; Severi, Gianluca ; Shen, Hui ; Shridhar, Vijayalakshmi ; Shu, Xiao-Ou ; Sieh, Weiva ; Southey, Melissa C ; Spellman, Paul ; Tajima, Kazuo ; Teo, Soo-Hwang ; Terry, Kathryn L ; Thompson, Pamela J ; Timorek, Agnieszka ; Tworoger, Shelley S ; van Altena, Anne M ; van den Berg, David ; Vergote, Ignace ; Vierkant, Robert A ; Vitonis, Allison F ; Wang-Gohrke, Shan ; Wentzensen, Nicolas ; Whittemore, Alice S ; Wik, Elisabeth ; Winterhoff, Boris ; Woo, Yin Ling ; Wu, Anna H ; Yang, Hannah P ; Zheng, Wei ; Ziogas, Argyrios ; Zulkifli, Famida ; Goodman, Marc T ; Hall, Per ; Easton, Douglas F ; Pearce, Celeste L ; Berchuck, Andrew ; Chenevix-Trench, Georgia ; Iversen, Edwin ; Monteiro, Alvaro N A ; Gayther, Simon A ; Schildkraut, Joellen M ; Sellers, Thomas A ; Study, Australian Cancer. / GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. I: Nature Genetics. 2013 ; Bind 45, Nr. 4. s. 362-70, 370e1-2.
Bibtex
@article{b46bca5e99f14c8b9a5ea524a6767848,
title = "GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer",
abstract = "Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10−9) and 10p12 (rs1243180, P = 1.8 × 10−8) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10−10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.",
author = "Pharoah, {Paul D P} and Ya-Yu Tsai and Ramus, {Susan J} and Phelan, {Catherine M} and Goode, {Ellen L} and Kate Lawrenson and Melissa Buckley and Fridley, {Brooke L} and Tyrer, {Jonathan P} and Howard Shen and Rachel Weber and Rod Karevan and Larson, {Melissa C} and Honglin Song and Tessier, {Daniel C} and Fran{\c c}ois Bacot and Daniel Vincent and Cunningham, {Julie M} and Joe Dennis and Ed Dicks and Aben, {Katja K} and Hoda Anton-Culver and Natalia Antonenkova and Armasu, {Sebastian M} and Laura Baglietto and Bandera, {Elisa V} and Beckmann, {Matthias W} and Birrer, {Michael J} and Greg Bloom and Natalia Bogdanova and Brenton, {James D} and Brinton, {Louise A} and Angela Brooks-Wilson and Brown, {Robert James (Jim)} and Ralf Butzow and Ian Campbell and Carney, {Michael E} and Carvalho, {Renato S} and Jenny Chang-Claude and Chen, {Y Anne} and Zhihua Chen and Wong-Ho Chow and Cicek, {Mine S} and Gerhard Coetzee and Cook, {Linda S} and Cramer, {Daniel W} and Cezary Cybulski and Agnieszka Dansonka-Mieszkowska and Evelyn Despierre and Doherty, {Jennifer A} and Thilo D{\"o}rk and {du Bois}, Andreas and Matthias D{\"u}rst and Diana Eccles and Robert Edwards and Ekici, {Arif B} and Fasching, {Peter A} and David Fenstermacher and James Flanagan and Yu-Tang Gao and Montserrat Garcia-Closas and Aleksandra Gentry-Maharaj and Graham Giles and Anxhela Gjyshi and Martin Gore and Jacek Gronwald and Qi Guo and Halle, {Mari K} and Philipp Harter and Alexander Hein and Florian Heitz and Peter Hillemanns and Maureen Hoatlin and Estrid H{\o}gdall and H{\o}gdall, {Claus K} and Satoyo Hosono and Anna Jakubowska and Allan Jensen and Kalli, {Kimberly R} and Karlan, {Beth Y} and Kelemen, {Linda E} and Kiemeney, {Lambertus A} and Kjaer, {Susanne Kr{\"u}ger} and Konecny, {Gottfried E} and Camilla Krakstad and Jolanta Kupryjanczyk and Diether Lambrechts and Sandrina Lambrechts and Le, {Nhu D} and Nathan Lee and Janet Lee and Arto Leminen and Lim, {Boon Kiong} and Jolanta Lissowska and Jan Lubi?ski and Lene Lundvall and Galina Lurie and Massuger, {Leon F A G} and Keitaro Matsuo and Valerie McGuire and McLaughlin, {John R} and Usha Menon and Francesmary Modugno and Moysich, {Kirsten B} and Toru Nakanishi and Narod, {Steven A} and Ness, {Roberta B} and Heli Nevanlinna and Stefan Nickels and Houtan Noushmehr and Kunle Odunsi and Sara Olson and Irene Orlow and James Paul and Tanja Pejovic and Pelttari, {Liisa M} and Jenny Permuth-Wey and Pike, {Malcolm C} and Poole, {Elizabeth M} and Xiaotao Qu and Risch, {Harvey A} and Lorna Rodriguez-Rodriguez and Rossing, {Mary Anne} and Anja Rudolph and Ingo Runnebaum and Rzepecka, {Iwona K} and Salvesen, {Helga B} and Ira Schwaab and Gianluca Severi and Hui Shen and Vijayalakshmi Shridhar and Xiao-Ou Shu and Weiva Sieh and Southey, {Melissa C} and Paul Spellman and Kazuo Tajima and Soo-Hwang Teo and Terry, {Kathryn L} and Thompson, {Pamela J} and Agnieszka Timorek and Tworoger, {Shelley S} and {van Altena}, {Anne M} and {van den Berg}, David and Ignace Vergote and Vierkant, {Robert A} and Vitonis, {Allison F} and Shan Wang-Gohrke and Nicolas Wentzensen and Whittemore, {Alice S} and Elisabeth Wik and Boris Winterhoff and Woo, {Yin Ling} and Wu, {Anna H} and Yang, {Hannah P} and Wei Zheng and Argyrios Ziogas and Famida Zulkifli and Goodman, {Marc T} and Per Hall and Easton, {Douglas F} and Pearce, {Celeste L} and Andrew Berchuck and Georgia Chenevix-Trench and Edwin Iversen and Monteiro, {Alvaro N A} and Gayther, {Simon A} and Schildkraut, {Joellen M} and Sellers, {Thomas A} and Study, {Australian Cancer}",
year = "2013",
month = apr,
doi = "10.1038/ng.2564",
language = "English",
volume = "45",
pages = "362--70, 370e1--2",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",
}
RIS
TY - JOUR
T1 - GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
AU - Pharoah, Paul D P
AU - Tsai, Ya-Yu
AU - Ramus, Susan J
AU - Phelan, Catherine M
AU - Goode, Ellen L
AU - Lawrenson, Kate
AU - Buckley, Melissa
AU - Fridley, Brooke L
AU - Tyrer, Jonathan P
AU - Shen, Howard
AU - Weber, Rachel
AU - Karevan, Rod
AU - Larson, Melissa C
AU - Song, Honglin
AU - Tessier, Daniel C
AU - Bacot, François
AU - Vincent, Daniel
AU - Cunningham, Julie M
AU - Dennis, Joe
AU - Dicks, Ed
AU - Aben, Katja K
AU - Anton-Culver, Hoda
AU - Antonenkova, Natalia
AU - Armasu, Sebastian M
AU - Baglietto, Laura
AU - Bandera, Elisa V
AU - Beckmann, Matthias W
AU - Birrer, Michael J
AU - Bloom, Greg
AU - Bogdanova, Natalia
AU - Brenton, James D
AU - Brinton, Louise A
AU - Brooks-Wilson, Angela
AU - Brown, Robert James (Jim)
AU - Butzow, Ralf
AU - Campbell, Ian
AU - Carney, Michael E
AU - Carvalho, Renato S
AU - Chang-Claude, Jenny
AU - Chen, Y Anne
AU - Chen, Zhihua
AU - Chow, Wong-Ho
AU - Cicek, Mine S
AU - Coetzee, Gerhard
AU - Cook, Linda S
AU - Cramer, Daniel W
AU - Cybulski, Cezary
AU - Dansonka-Mieszkowska, Agnieszka
AU - Despierre, Evelyn
AU - Doherty, Jennifer A
AU - Dörk, Thilo
AU - du Bois, Andreas
AU - Dürst, Matthias
AU - Eccles, Diana
AU - Edwards, Robert
AU - Ekici, Arif B
AU - Fasching, Peter A
AU - Fenstermacher, David
AU - Flanagan, James
AU - Gao, Yu-Tang
AU - Garcia-Closas, Montserrat
AU - Gentry-Maharaj, Aleksandra
AU - Giles, Graham
AU - Gjyshi, Anxhela
AU - Gore, Martin
AU - Gronwald, Jacek
AU - Guo, Qi
AU - Halle, Mari K
AU - Harter, Philipp
AU - Hein, Alexander
AU - Heitz, Florian
AU - Hillemanns, Peter
AU - Hoatlin, Maureen
AU - Høgdall, Estrid
AU - Høgdall, Claus K
AU - Hosono, Satoyo
AU - Jakubowska, Anna
AU - Jensen, Allan
AU - Kalli, Kimberly R
AU - Karlan, Beth Y
AU - Kelemen, Linda E
AU - Kiemeney, Lambertus A
AU - Kjaer, Susanne Krüger
AU - Konecny, Gottfried E
AU - Krakstad, Camilla
AU - Kupryjanczyk, Jolanta
AU - Lambrechts, Diether
AU - Lambrechts, Sandrina
AU - Le, Nhu D
AU - Lee, Nathan
AU - Lee, Janet
AU - Leminen, Arto
AU - Lim, Boon Kiong
AU - Lissowska, Jolanta
AU - Lubi?ski, Jan
AU - Lundvall, Lene
AU - Lurie, Galina
AU - Massuger, Leon F A G
AU - Matsuo, Keitaro
AU - McGuire, Valerie
AU - McLaughlin, John R
AU - Menon, Usha
AU - Modugno, Francesmary
AU - Moysich, Kirsten B
AU - Nakanishi, Toru
AU - Narod, Steven A
AU - Ness, Roberta B
AU - Nevanlinna, Heli
AU - Nickels, Stefan
AU - Noushmehr, Houtan
AU - Odunsi, Kunle
AU - Olson, Sara
AU - Orlow, Irene
AU - Paul, James
AU - Pejovic, Tanja
AU - Pelttari, Liisa M
AU - Permuth-Wey, Jenny
AU - Pike, Malcolm C
AU - Poole, Elizabeth M
AU - Qu, Xiaotao
AU - Risch, Harvey A
AU - Rodriguez-Rodriguez, Lorna
AU - Rossing, Mary Anne
AU - Rudolph, Anja
AU - Runnebaum, Ingo
AU - Rzepecka, Iwona K
AU - Salvesen, Helga B
AU - Schwaab, Ira
AU - Severi, Gianluca
AU - Shen, Hui
AU - Shridhar, Vijayalakshmi
AU - Shu, Xiao-Ou
AU - Sieh, Weiva
AU - Southey, Melissa C
AU - Spellman, Paul
AU - Tajima, Kazuo
AU - Teo, Soo-Hwang
AU - Terry, Kathryn L
AU - Thompson, Pamela J
AU - Timorek, Agnieszka
AU - Tworoger, Shelley S
AU - van Altena, Anne M
AU - van den Berg, David
AU - Vergote, Ignace
AU - Vierkant, Robert A
AU - Vitonis, Allison F
AU - Wang-Gohrke, Shan
AU - Wentzensen, Nicolas
AU - Whittemore, Alice S
AU - Wik, Elisabeth
AU - Winterhoff, Boris
AU - Woo, Yin Ling
AU - Wu, Anna H
AU - Yang, Hannah P
AU - Zheng, Wei
AU - Ziogas, Argyrios
AU - Zulkifli, Famida
AU - Goodman, Marc T
AU - Hall, Per
AU - Easton, Douglas F
AU - Pearce, Celeste L
AU - Berchuck, Andrew
AU - Chenevix-Trench, Georgia
AU - Iversen, Edwin
AU - Monteiro, Alvaro N A
AU - Gayther, Simon A
AU - Schildkraut, Joellen M
AU - Sellers, Thomas A
AU - Study, Australian Cancer
PY - 2013/4
Y1 - 2013/4
N2 - Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10−9) and 10p12 (rs1243180, P = 1.8 × 10−8) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10−10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
AB - Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10−9) and 10p12 (rs1243180, P = 1.8 × 10−8) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10−10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
U2 - 10.1038/ng.2564
DO - 10.1038/ng.2564
M3 - Journal article
VL - 45
SP - 362-70, 370e1-2
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
