Gut microbiota and depressive symptoms
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Gut microbiota and depressive symptoms. / Knudsen, Julie Kristine; Jensen, Zenia Funch; Christensen, Alice Højer; Günther, Stig; Nielsen, Lene Nørby; Deutscher, Peter; Arnfred, Sidse.
I: Ugeskrift for Laeger, Bind 179, Nr. 47, 20.11.2017.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Gut microbiota and depressive symptoms
AU - Knudsen, Julie Kristine
AU - Jensen, Zenia Funch
AU - Christensen, Alice Højer
AU - Günther, Stig
AU - Nielsen, Lene Nørby
AU - Deutscher, Peter
AU - Arnfred, Sidse
PY - 2017/11/20
Y1 - 2017/11/20
N2 - The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial signalling to the host through metabolic, endocrinal, immunologic and neuronal pathways. Few studies of patients with depression have shown altered microbiota profiles and increased levels of systemic endotoxin, which can be detected by leucocytes and result in expression of cytokines. Studies performed so far have lacked statistical power and provide no causal explanation for the gut-brain hypothesis. Further research into the matter is certainly warranted.
AB - The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial signalling to the host through metabolic, endocrinal, immunologic and neuronal pathways. Few studies of patients with depression have shown altered microbiota profiles and increased levels of systemic endotoxin, which can be detected by leucocytes and result in expression of cytokines. Studies performed so far have lacked statistical power and provide no causal explanation for the gut-brain hypothesis. Further research into the matter is certainly warranted.
M3 - Review
C2 - 29208194
AN - SCOPUS:85060128220
VL - 179
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 47
ER -
ID: 245373508