Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production
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Sencio et al. provide insights into the mechanisms that underlie bacterial superinfection post-influenza. The authors demonstrate that influenza infection remotely alters the production of short-chain fatty acids (SCFAs) by the gut microbiota. Supplementation with acetate or pharmacological activation of the SCFA receptor FFAR2 reduces susceptibility to secondary bacterial infection.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Cell Reports |
Vol/bind | 30 |
Udgave nummer | 9 |
Sider (fra-til) | 2934-2947.e6 |
ISSN | 2211-1247 |
DOI | |
Status | Udgivet - 3 mar. 2020 |
ID: 239723525