Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Objective: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies. Methods: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls. Results and conclusions: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.
Originalsprog | Engelsk |
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Tidsskrift | Mitochondrion |
Vol/bind | 50 |
Sider (fra-til) | 35-41 |
ISSN | 1567-7249 |
DOI | |
Status | Udgivet - jan. 2020 |
ID: 240243210