Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys
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Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys. / Darusman, Huda S.; Agungpriyono, Dewi Ratih; Kusumaputri, Vinka A.; Sajuthi, Dondin; Schapiro, Steven J.; Hau, Jann.
I: Frontiers in Aging Neuroscience, Bind 11, 50, 07.03.2019, s. 1-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys
AU - Darusman, Huda S.
AU - Agungpriyono, Dewi Ratih
AU - Kusumaputri, Vinka A.
AU - Sajuthi, Dondin
AU - Schapiro, Steven J.
AU - Hau, Jann
PY - 2019/3/7
Y1 - 2019/3/7
N2 - Neurons with histopathological changes consistent with granulovacuolar degeneration(GVD) were found in brain sections from aged cynomolgus monkeys (Macacafascicularis) with clinical and pathological signs of cognitive aging. To our knowledge,this is the first reported description of GVD in non-human primates. GVD-like lesionswere found also in age-matched cognitively healthy subjects, albeit in lower numbers,suggesting that they may relate to aging and the increase may have tendency toincrease with the memory deficits. The increased incidence of GVD-like lesions inmemory-impaired subjects with pahological backgrounds of senile plaques (SPs) andtauopathy is, however, an interesting observation of relevance to the characterization ofpathologies in the spontaneous cynomolgus monkey model of human Alzheimer’s typeof brain pathology.
AB - Neurons with histopathological changes consistent with granulovacuolar degeneration(GVD) were found in brain sections from aged cynomolgus monkeys (Macacafascicularis) with clinical and pathological signs of cognitive aging. To our knowledge,this is the first reported description of GVD in non-human primates. GVD-like lesionswere found also in age-matched cognitively healthy subjects, albeit in lower numbers,suggesting that they may relate to aging and the increase may have tendency toincrease with the memory deficits. The increased incidence of GVD-like lesions inmemory-impaired subjects with pahological backgrounds of senile plaques (SPs) andtauopathy is, however, an interesting observation of relevance to the characterization ofpathologies in the spontaneous cynomolgus monkey model of human Alzheimer’s typeof brain pathology.
KW - non-human primate
KW - neurodegenerative disease
KW - Alzheimer's disease
KW - aging
KW - histopathology
KW - spontaneous lessions
U2 - 10.3389/fnagi.2019.00050
DO - 10.3389/fnagi.2019.00050
M3 - Journal article
C2 - 30899220
VL - 11
SP - 1
EP - 5
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
SN - 1663-4365
M1 - 50
ER -
ID: 223975829