Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies
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Grain and dietary fiber intake and bladder cancer risk : a pooled analysis of prospective cohort studies. / Yu, Evan Y.W.; Wesselius, Anke; Mehrkanoon, Siamak; Brinkman, Maree; van den Brandt, Piet; White, Emily; Weiderpass, Elisabete; Le Calvez-Kelm, Florence; Gunter, Marc; Huybrechts, Inge; Liedberg, Fredrik; Skeie, Guri; Tjonneland, Anne; Riboli, Elio; Giles, Graham G.; Milne, Roger L.; Zeegers, Maurice P.
I: American Journal of Clinical Nutrition, Bind 112, Nr. 5, 11.11.2020, s. 1252-1266.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Grain and dietary fiber intake and bladder cancer risk
T2 - a pooled analysis of prospective cohort studies
AU - Yu, Evan Y.W.
AU - Wesselius, Anke
AU - Mehrkanoon, Siamak
AU - Brinkman, Maree
AU - van den Brandt, Piet
AU - White, Emily
AU - Weiderpass, Elisabete
AU - Le Calvez-Kelm, Florence
AU - Gunter, Marc
AU - Huybrechts, Inge
AU - Liedberg, Fredrik
AU - Skeie, Guri
AU - Tjonneland, Anne
AU - Riboli, Elio
AU - Giles, Graham G.
AU - Milne, Roger L.
AU - Zeegers, Maurice P.
PY - 2020/11/11
Y1 - 2020/11/11
N2 - BACKGROUND: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer. OBJECTIVES: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber. METHODS: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs, were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models. RESULTS: We found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91; 95% CI: 0.82, 0.98; P for trend: 0.021). In addition, dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism. CONCLUSIONS: Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.
AB - BACKGROUND: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer. OBJECTIVES: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber. METHODS: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs, were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models. RESULTS: We found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91; 95% CI: 0.82, 0.98; P for trend: 0.021). In addition, dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism. CONCLUSIONS: Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.
KW - bladder cancer
KW - cohort study
KW - dietary fiber
KW - dose-response analysis
KW - grain
U2 - 10.1093/ajcn/nqaa215
DO - 10.1093/ajcn/nqaa215
M3 - Journal article
C2 - 32778880
AN - SCOPUS:85096152830
VL - 112
SP - 1252
EP - 1266
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -
ID: 252930730