GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance
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GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance. / Kampmann, Ulla; Christensen, Britt; Nielsen, Thomas Svava; Pedersen, Steen Bønløkke; Ørskov, Lotte; Lund, Sten; Møller, Niels; Jessen, Niels.
I: PLOS ONE, Bind 6, Nr. 11, 2011, s. e27854.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance
AU - Kampmann, Ulla
AU - Christensen, Britt
AU - Nielsen, Thomas Svava
AU - Pedersen, Steen Bønløkke
AU - Ørskov, Lotte
AU - Lund, Sten
AU - Møller, Niels
AU - Jessen, Niels
PY - 2011
Y1 - 2011
N2 - Subgroups of patients with type 2 diabetes mellitus demand large insulin doses to maintain euglycemia. These patients are characterized by severe skeletal muscle insulin resistance and the underlying pathology remains unclear. The purpose of this study was to examine protein expression of the principal glucose transporter, GLUT4, and associated proteins in skeletal muscle from type 2 diabetic patients characterized by severe insulin resistance.
AB - Subgroups of patients with type 2 diabetes mellitus demand large insulin doses to maintain euglycemia. These patients are characterized by severe skeletal muscle insulin resistance and the underlying pathology remains unclear. The purpose of this study was to examine protein expression of the principal glucose transporter, GLUT4, and associated proteins in skeletal muscle from type 2 diabetic patients characterized by severe insulin resistance.
KW - Blotting, Western
KW - Case-Control Studies
KW - Diabetes Mellitus, Type 2
KW - Female
KW - Glucose Transporter Type 4
KW - Humans
KW - Insulin Resistance
KW - Male
KW - Middle Aged
KW - Muscle, Skeletal
KW - RNA, Messenger
KW - Real-Time Polymerase Chain Reaction
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Ubiquitin-Conjugating Enzymes
U2 - 10.1371/journal.pone.0027854
DO - 10.1371/journal.pone.0027854
M3 - Journal article
C2 - 22114711
VL - 6
SP - e27854
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
ER -
ID: 101699809