Glucagon-like peptide 1--a cardiologic dimension
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Glucagon-like peptide 1--a cardiologic dimension. / Treiman, Marek; Elvekjaer, Mikkel; Engstrøm, Thomas; Jensen, Jan Skov.
I: Trends in Cardiovascular Medicine, Bind 20, Nr. 1, 01.01.2010, s. 8-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glucagon-like peptide 1--a cardiologic dimension
AU - Treiman, Marek
AU - Elvekjaer, Mikkel
AU - Engstrøm, Thomas
AU - Jensen, Jan Skov
N1 - (c) 2010 Elsevier Inc. All rights reserved.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Recent experimental data suggest glucagon-like peptide 1 (GLP-1) and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. These direct effects may be cardioprotective, contractility augmenting, and vasorelaxant. A few preliminary clinical trials appear to support a mechanical function improvement after GLP-1 administration to patients with a weakened left ventricle. Based on animal studies, diminished lethal injury to the postischemic reperfused myocardium appears to be a particularly promising prospect, awaiting to be tested in clinical settings.
AB - Recent experimental data suggest glucagon-like peptide 1 (GLP-1) and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. These direct effects may be cardioprotective, contractility augmenting, and vasorelaxant. A few preliminary clinical trials appear to support a mechanical function improvement after GLP-1 administration to patients with a weakened left ventricle. Based on animal studies, diminished lethal injury to the postischemic reperfused myocardium appears to be a particularly promising prospect, awaiting to be tested in clinical settings.
KW - Animals
KW - Blood Pressure
KW - Cardiovascular Agents
KW - Glucagon-Like Peptide 1
KW - Heart Diseases
KW - Humans
KW - Myocardial Contraction
KW - Myocardial Reperfusion Injury
KW - Signal Transduction
KW - Treatment Outcome
KW - Vasodilation
KW - Ventricular Function, Left
U2 - 10.1016/j.tcm.2010.02.012
DO - 10.1016/j.tcm.2010.02.012
M3 - Journal article
C2 - 20685571
VL - 20
SP - 8
EP - 12
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
SN - 1050-1738
IS - 1
ER -
ID: 33870091