GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle. / Sjøberg, Kim Anker; Holst, Jens Juul; Rattigan, Stephen; Richter, Erik A.; Kiens, Bente.
I: American Journal of Physiology: Endocrinology and Metabolism, Bind 306, Nr. 4, 2014, s. E355-E362.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle
AU - Sjøberg, Kim Anker
AU - Holst, Jens Juul
AU - Rattigan, Stephen
AU - Richter, Erik A.
AU - Kiens, Bente
N1 - CURIS 2014 NEXS 054
PY - 2014
Y1 - 2014
N2 - The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P
AB - The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P
U2 - 10.1152/ajpendo.00283.2013
DO - 10.1152/ajpendo.00283.2013
M3 - Journal article
C2 - 24302010
VL - 306
SP - E355-E362
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 4
ER -
ID: 92062721