Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study
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Glioma-related seizures in relation to histopathological subtypes : a report from the glioma international case–control study. / Berntsson, Shala G.; Merrell, Ryan T.; Amirian, E. Susan; Armstrong, Georgina N.; Lachance, Daniel; Smits, Anja; Zhou, Renke; Jacobs, Daniel I.; Wrensch, Margaret R.; Olson, Sara H.; Il’yasova, Dora; Claus, Elizabeth B.; Barnholtz-Sloan, Jill S.; Schildkraut, Joellen; Sadetzki, Siegal; Johansen, Christoffer; Houlston, Richard S.; Jenkins, Robert B.; Bernstein, Jonine L.; Lai, Rose; Shete, Sanjay; Amos, Christopher I.; Bondy, Melissa L.; Melin, Beatrice S.
I: Journal of Neurology, Bind 265, Nr. 6, 2018, s. 1432-1442.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glioma-related seizures in relation to histopathological subtypes
T2 - a report from the glioma international case–control study
AU - Berntsson, Shala G.
AU - Merrell, Ryan T.
AU - Amirian, E. Susan
AU - Armstrong, Georgina N.
AU - Lachance, Daniel
AU - Smits, Anja
AU - Zhou, Renke
AU - Jacobs, Daniel I.
AU - Wrensch, Margaret R.
AU - Olson, Sara H.
AU - Il’yasova, Dora
AU - Claus, Elizabeth B.
AU - Barnholtz-Sloan, Jill S.
AU - Schildkraut, Joellen
AU - Sadetzki, Siegal
AU - Johansen, Christoffer
AU - Houlston, Richard S.
AU - Jenkins, Robert B.
AU - Bernstein, Jonine L.
AU - Lai, Rose
AU - Shete, Sanjay
AU - Amos, Christopher I.
AU - Bondy, Melissa L.
AU - Melin, Beatrice S.
PY - 2018
Y1 - 2018
N2 - Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.
AB - Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.
KW - Epileptic seizures
KW - Glioma-related seizures
KW - Observational study (cohort, case–control)
KW - Primary brain tumor
U2 - 10.1007/s00415-018-8857-0
DO - 10.1007/s00415-018-8857-0
M3 - Journal article
C2 - 29687214
AN - SCOPUS:85045844511
VL - 265
SP - 1432
EP - 1442
JO - Deutsche Zeitschrift fur Nervenheilkunde
JF - Deutsche Zeitschrift fur Nervenheilkunde
SN - 0939-1517
IS - 6
ER -
ID: 209800164